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Metabolic engineering and adaptive laboratory evolution enhance squalene production in Yarrowia lipolytica.

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Title: Metabolic engineering and adaptive laboratory evolution enhance squalene production in Yarrowia lipolytica.
Authors: Zhao QQ; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China., Hu PC; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China., Zhang CJ; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China., Zhu MY; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China., Tian Y; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China., Yang XN; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China., Ji XJ; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, 211816, China., Li CZ; State Key Laboratory of Utilization of Woody Oil Resource, Hunan Academy of Forestry, Changsha, Hunan, 410004, China., Sun XM; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, Jiangsu, 210023, China., Lu XY; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China., Liu HH; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.; State Key Laboratory of Microbial Technology, Nanjing, Jiangsu, 210023, China.
Source: Synthetic and systems biotechnology [Synth Syst Biotechnol] 2026 Jan 30; Vol. 13, pp. 86-97. Date of Electronic Publication: 2026 Jan 30 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: KeAi Communications Co Country of Publication: China NLM ID: 101694371 Publication Model: eCollection Cited Medium: Internet ISSN: 2405-805X (Electronic) Linking ISSN: 2405805X NLM ISO Abbreviation: Synth Syst Biotechnol Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Metabolic engineering and adaptive laboratory evolution enhance squalene production in Yarrowia lipolytica.
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  Data: <searchLink fieldCode="AU" term="%22Zhao+QQ%22">Zhao QQ</searchLink>; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.<br /><searchLink fieldCode="AU" term="%22Hu+PC%22">Hu PC</searchLink>; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.<br /><searchLink fieldCode="AU" term="%22Zhang+CJ%22">Zhang CJ</searchLink>; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.<br /><searchLink fieldCode="AU" term="%22Zhu+MY%22">Zhu MY</searchLink>; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.<br /><searchLink fieldCode="AU" term="%22Tian+Y%22">Tian Y</searchLink>; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.<br /><searchLink fieldCode="AU" term="%22Yang+XN%22">Yang XN</searchLink>; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.<br /><searchLink fieldCode="AU" term="%22Ji+XJ%22">Ji XJ</searchLink>; College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, Jiangsu, 211816, China.<br /><searchLink fieldCode="AU" term="%22Li+CZ%22">Li CZ</searchLink>; State Key Laboratory of Utilization of Woody Oil Resource, Hunan Academy of Forestry, Changsha, Hunan, 410004, China.<br /><searchLink fieldCode="AU" term="%22Sun+XM%22">Sun XM</searchLink>; School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing, Jiangsu, 210023, China.<br /><searchLink fieldCode="AU" term="%22Lu+XY%22">Lu XY</searchLink>; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.<br /><searchLink fieldCode="AU" term="%22Liu+HH%22">Liu HH</searchLink>; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan, 410128, China.; State Key Laboratory of Microbial Technology, Nanjing, Jiangsu, 210023, China.
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  Data: <searchLink fieldCode="JN" term="%22101694371%22">Synthetic and systems biotechnology</searchLink> [Synth Syst Biotechnol] 2026 Jan 30; Vol. 13, pp. 86-97. <i>Date of Electronic Publication: </i>2026 Jan 30 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22KeAi+Communications+Co%22">KeAi Communications Co </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>101694371 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2405-805X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222405805X%22">2405805X </searchLink><i>NLM ISO Abbreviation: </i>Synth Syst Biotechnol <i>Subsets: </i>PubMed not MEDLINE
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      – Type: doi
        Value: 10.1016/j.synbio.2026.01.017
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      – Code: eng
        Text: English
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      – TitleFull: Metabolic engineering and adaptive laboratory evolution enhance squalene production in Yarrowia lipolytica.
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              Text: 2026 Jan 30
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