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Educational attainment is associated with reduced functional decline in Puerto Ricans with elevated pTau181.

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Title: Educational attainment is associated with reduced functional decline in Puerto Ricans with elevated pTau181.
Authors: Dorfsman DA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA., Cai D; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Hamilton-Nelson KL; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Adams LD; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Mena PR; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Rodriguez VC; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Sanchez JJ; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Valladares GS; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Lopez M; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Whitehead PL; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Prough MB; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Manrique P; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Martinez A; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Mas SM; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Scaramutti C; Department of Informatics and Health Data Science, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA., Acosta H; Clinica de la Memoria, San Juan, PR, USA., Silva-Vergara C; Universidad Central del Caribe, Bayamón, PR, USA., McInerney K; Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA., Griswold AJ; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA., Feliciano-Astacio BE; Universidad Central del Caribe, Bayamón, PR, USA., Cuccaro ML; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA., Kunkle BW; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA., Reitz C; Gertrude H. Sergievsky Center, Taub Institute for Research on the Aging Brain, Department of Neurology, Psychiatry, and Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Tosto G; Gertrude H. Sergievsky Center, Taub Institute for Research on the Aging Brain, Department of Neurology, Psychiatry, and Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Bush WS; Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Haines JL; Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Akinyemi JO; Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria., Akinyemi RO; Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria., Ogunniyi A; Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria., Byrd GS; Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Vance JM; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA., Celis K; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA., Seixas A; Department of Informatics and Health Data Science, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA., Pericak-Vance MA; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA., Rajabli F; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.
Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2026 Mar; Vol. 110 (2), pp. 685-695. Date of Electronic Publication: 2026 Feb 09.
Publication Type: Journal Article
Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE
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  Data: Educational attainment is associated with reduced functional decline in Puerto Ricans with elevated pTau181.
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Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Feliciano-Astacio+BE%22">Feliciano-Astacio BE</searchLink>; Universidad Central del Caribe, Bayamón, PR, USA.<br /><searchLink fieldCode="AU" term="%22Cuccaro+ML%22">Cuccaro ML</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Kunkle+BW%22">Kunkle BW</searchLink>; John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.; Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Reitz+C%22">Reitz C</searchLink>; Gertrude H. Sergievsky Center, Taub Institute for Research on the Aging Brain, Department of Neurology, Psychiatry, and Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tosto+G%22">Tosto G</searchLink>; Gertrude H. Sergievsky Center, Taub Institute for Research on the Aging Brain, Department of Neurology, Psychiatry, and Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bush+WS%22">Bush WS</searchLink>; Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Haines+JL%22">Haines JL</searchLink>; Cleveland Institute for Computational Biology, Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Akinyemi+JO%22">Akinyemi JO</searchLink>; Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Akinyemi+RO%22">Akinyemi RO</searchLink>; Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Ogunniyi+A%22">Ogunniyi A</searchLink>; Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria.<br /><searchLink fieldCode="AU" term="%22Byrd+GS%22">Byrd GS</searchLink>; Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, NC, USA.<br /><searchLink fieldCode="AU" term="%22Vance+JM%22">Vance JM</searchLink>; John P. 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