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Regnase-1-mediated regulation of neutrophils modulates SARS-CoV-2 pneumonia.

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Title: Regnase-1-mediated regulation of neutrophils modulates SARS-CoV-2 pneumonia.
Authors: Yasuda K; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan., Aoki J; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan., Tanaka K; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Shichinohe S; Department of Molecular Virology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan., Ono C; Laboratory of Virus Control, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.; Center for Infectious Disease Education and Research, The University of Osaka, Suita, Japan.; Center for Advanced Modalities and DDS, The University of Osaka, Suita, Japan., Vandenbon A; Laboratory of Tissue Homeostasis, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Ohara D; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Muramoto Y; Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Li S; Department of Genome Informatics, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan., Motooka D; NGS core facility, Bioinformatics Center, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan., Watanabe H; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Hirota K; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Kondoh G; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Noda T; Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., Standley DM; Department of Genome Informatics, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan., Ikehara Y; Department of Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan., Okada S; Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan., Watanabe T; Department of Molecular Virology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.; Center for Infectious Disease Education and Research, The University of Osaka, Suita, Japan.; Center for Advanced Modalities and DDS, The University of Osaka, Suita, Japan., Matsuura Y; Laboratory of Virus Control, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.; Center for Infectious Disease Education and Research, The University of Osaka, Suita, Japan.; Center for Advanced Modalities and DDS, The University of Osaka, Suita, Japan., Takeuchi O; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Source: PLoS pathogens [PLoS Pathog] 2026 Feb 09; Vol. 22 (2), pp. e1013969. Date of Electronic Publication: 2026 Feb 09 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Regnase-1-mediated regulation of neutrophils modulates SARS-CoV-2 pneumonia.
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  Data: <searchLink fieldCode="AU" term="%22Yasuda+K%22">Yasuda K</searchLink>; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Aoki+J%22">Aoki J</searchLink>; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Tanaka+K%22">Tanaka K</searchLink>; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Shichinohe+S%22">Shichinohe S</searchLink>; Department of Molecular Virology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Ono+C%22">Ono C</searchLink>; Laboratory of Virus Control, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.; Center for Infectious Disease Education and Research, The University of Osaka, Suita, Japan.; Center for Advanced Modalities and DDS, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Vandenbon+A%22">Vandenbon A</searchLink>; Laboratory of Tissue Homeostasis, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ohara+D%22">Ohara D</searchLink>; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Muramoto+Y%22">Muramoto Y</searchLink>; Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Department of Genome Informatics, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Motooka+D%22">Motooka D</searchLink>; NGS core facility, Bioinformatics Center, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+H%22">Watanabe H</searchLink>; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Hirota+K%22">Hirota K</searchLink>; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Kondoh+G%22">Kondoh G</searchLink>; Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Noda+T%22">Noda T</searchLink>; Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Standley+DM%22">Standley DM</searchLink>; Department of Genome Informatics, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Ikehara+Y%22">Ikehara Y</searchLink>; Department of Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan.<br /><searchLink fieldCode="AU" term="%22Okada+S%22">Okada S</searchLink>; Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Watanabe+T%22">Watanabe T</searchLink>; Department of Molecular Virology, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.; Center for Infectious Disease Education and Research, The University of Osaka, Suita, Japan.; Center for Advanced Modalities and DDS, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuura+Y%22">Matsuura Y</searchLink>; Laboratory of Virus Control, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.; Center for Infectious Disease Education and Research, The University of Osaka, Suita, Japan.; Center for Advanced Modalities and DDS, The University of Osaka, Suita, Japan.<br /><searchLink fieldCode="AU" term="%22Takeuchi+O%22">Takeuchi O</searchLink>; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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