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The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains.

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Title: The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains.
Authors: Eraña H; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain.; ATLAS Molecular Pharma S. L., Derio, Spain., Vidal E; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.; Unitat mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain., Fernández-Borges N; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Charco JM; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain.; ATLAS Molecular Pharma S. L., Derio, Spain., Díaz-Domínguez CM; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Sampedro-Torres-Quevedo C; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain., Galarza-Ahumada J; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Fernández-Muñoz E; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., San-Juan-Ansoleaga M; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Pérez-Castro MÁ; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Gonçalves-Anjo N; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Piñeiro P; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain., Giler S; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.; Unitat mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain., González-Martín N; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain., Lorenzo NL; CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago, Spain., Manero-Azua A; Molecular (Epi)Genetics Laboratory, Bioaraba Health Research Institute, Araba University Hospital, Vitoria-Gasteiz, Spain., Perez de Nanclares G; Molecular (Epi)Genetics Laboratory, Bioaraba Health Research Institute, Araba University Hospital, Vitoria-Gasteiz, Spain., Geijo M; Animal Health Department, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Derio, Spain., Sánchez-Martín MA; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.; Transgenic Facility, Department of Medicine, University of Salamanca, Salamanca, Spain., Requena JR; CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago, Spain., Castilla J; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
Source: Brain pathology (Zurich, Switzerland) [Brain Pathol] 2026 Jul; Vol. 36 (4), pp. e70083. Date of Electronic Publication: 2026 Feb 09.
Publication Type: Journal Article
Journal Info: Publisher: International Society of Neuropathology Country of Publication: Switzerland NLM ID: 9216781 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-3639 (Electronic) Linking ISSN: 10156305 NLM ISO Abbreviation: Brain Pathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains.
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  Data: <searchLink fieldCode="AU" term="%22Eraña+H%22">Eraña H</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain.; ATLAS Molecular Pharma S. L., Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Vidal+E%22">Vidal E</searchLink>; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.; Unitat mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Borges+N%22">Fernández-Borges N</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Charco+JM%22">Charco JM</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain.; ATLAS Molecular Pharma S. L., Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Díaz-Domínguez+CM%22">Díaz-Domínguez CM</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Sampedro-Torres-Quevedo+C%22">Sampedro-Torres-Quevedo C</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Galarza-Ahumada+J%22">Galarza-Ahumada J</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Muñoz+E%22">Fernández-Muñoz E</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22San-Juan-Ansoleaga+M%22">San-Juan-Ansoleaga M</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Pérez-Castro+MÁ%22">Pérez-Castro MÁ</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Gonçalves-Anjo+N%22">Gonçalves-Anjo N</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Piñeiro+P%22">Piñeiro P</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Giler+S%22">Giler S</searchLink>; IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.; Unitat mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.<br /><searchLink fieldCode="AU" term="%22González-Martín+N%22">González-Martín N</searchLink>; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Lorenzo+NL%22">Lorenzo NL</searchLink>; CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago, Spain.<br /><searchLink fieldCode="AU" term="%22Manero-Azua+A%22">Manero-Azua A</searchLink>; Molecular (Epi)Genetics Laboratory, Bioaraba Health Research Institute, Araba University Hospital, Vitoria-Gasteiz, Spain.<br /><searchLink fieldCode="AU" term="%22Perez+de+Nanclares+G%22">Perez de Nanclares G</searchLink>; Molecular (Epi)Genetics Laboratory, Bioaraba Health Research Institute, Araba University Hospital, Vitoria-Gasteiz, Spain.<br /><searchLink fieldCode="AU" term="%22Geijo+M%22">Geijo M</searchLink>; Animal Health Department, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez-Martín+MA%22">Sánchez-Martín MA</searchLink>; Institute for Biomedical Research of Salamanca (IBSAL), Salamanca, Spain.; Transgenic Facility, Department of Medicine, University of Salamanca, Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Requena+JR%22">Requena JR</searchLink>; CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago, Spain.<br /><searchLink fieldCode="AU" term="%22Castilla+J%22">Castilla J</searchLink>; Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain.; Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
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  Data: <searchLink fieldCode="JN" term="%229216781%22">Brain pathology (Zurich, Switzerland)</searchLink> [Brain Pathol] 2026 Jul; Vol. 36 (4), pp. e70083. <i>Date of Electronic Publication: </i>2026 Feb 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22International+Society+of+Neuropathology%22">International Society of Neuropathology </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9216781 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1750-3639 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210156305%22">10156305 </searchLink><i>NLM ISO Abbreviation: </i>Brain Pathol <i>Subsets: </i>MEDLINE
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