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Mammalian mitochondrial DNA accumulates insertions and deletions with age in energetically demanding tissues.

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Title: Mammalian mitochondrial DNA accumulates insertions and deletions with age in energetically demanding tissues.
Authors: Torres-Gonzalez E; Department of Biology, The Pennsylvania State University, University Park, PA, USA.; Huck Life Sciences Institutes, The Pennsylvania State University, University Park, PA, USA., Arbeithuber B; Department of Biology, The Pennsylvania State University, University Park, PA, USA.; Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Kepler Universitätsklinikum, Linz, Austria., Stoler N; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA.; National Center for Biotechnology Information, The National Institutes of Health, Bethesda, MD, USA., Cremona MA; Center for Medical Genomics, The Pennsylvania State University, University Park, PA, USA.; Chair in Statistical Learning, Department of Operations and Decision Systems, Université Laval, Québec City, Québec, Canada.; Université Laval Research Center, CHU de Québec, Québec City, Québec, Canada., Shebl O; Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Kepler Universitätsklinikum, Linz, Austria., Ebner T; Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Kepler Universitätsklinikum, Linz, Austria., Tiemann-Boege I; Institute of Biophysics, Johannes Kepler University, Linz, Austria., Diaz FJ; Department of Animal Science, Pennsylvania State University, University Park, PA, USA., Chiaromonte F; Center for Medical Genomics, The Pennsylvania State University, University Park, PA, USA.; Department of Statistics, Pennsylvania State University, University Park, PA, USA.; Sant'Anna School of Advanced Studies, L'EMbeDS, Pisa, Italy., Makova KD; Department of Biology, The Pennsylvania State University, University Park, PA, USA.; Center for Medical Genomics, The Pennsylvania State University, University Park, PA, USA.
Source: Molecular biology and evolution [Mol Biol Evol] 2026 Mar 02; Vol. 43 (3).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 8501455 Publication Model: Print Cited Medium: Internet ISSN: 1537-1719 (Electronic) Linking ISSN: 07374038 NLM ISO Abbreviation: Mol Biol Evol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mammalian mitochondrial DNA accumulates insertions and deletions with age in energetically demanding tissues.
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  Data: <searchLink fieldCode="AU" term="%22Torres-Gonzalez+E%22">Torres-Gonzalez E</searchLink>; Department of Biology, The Pennsylvania State University, University Park, PA, USA.; Huck Life Sciences Institutes, The Pennsylvania State University, University Park, PA, USA.<br /><searchLink fieldCode="AU" term="%22Arbeithuber+B%22">Arbeithuber B</searchLink>; Department of Biology, The Pennsylvania State University, University Park, PA, USA.; Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Kepler Universitätsklinikum, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Stoler+N%22">Stoler N</searchLink>; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, USA.; National Center for Biotechnology Information, The National Institutes of Health, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Cremona+MA%22">Cremona MA</searchLink>; Center for Medical Genomics, The Pennsylvania State University, University Park, PA, USA.; Chair in Statistical Learning, Department of Operations and Decision Systems, Université Laval, Québec City, Québec, Canada.; Université Laval Research Center, CHU de Québec, Québec City, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Shebl+O%22">Shebl O</searchLink>; Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Kepler Universitätsklinikum, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Ebner+T%22">Ebner T</searchLink>; Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Kepler Universitätsklinikum, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Tiemann-Boege+I%22">Tiemann-Boege I</searchLink>; Institute of Biophysics, Johannes Kepler University, Linz, Austria.<br /><searchLink fieldCode="AU" term="%22Diaz+FJ%22">Diaz FJ</searchLink>; Department of Animal Science, Pennsylvania State University, University Park, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chiaromonte+F%22">Chiaromonte F</searchLink>; Center for Medical Genomics, The Pennsylvania State University, University Park, PA, USA.; Department of Statistics, Pennsylvania State University, University Park, PA, USA.; Sant'Anna School of Advanced Studies, L'EMbeDS, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Makova+KD%22">Makova KD</searchLink>; Department of Biology, The Pennsylvania State University, University Park, PA, USA.; Center for Medical Genomics, The Pennsylvania State University, University Park, PA, USA.
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  Data: <searchLink fieldCode="JN" term="%228501455%22">Molecular biology and evolution</searchLink> [Mol Biol Evol] 2026 Mar 02; Vol. 43 (3).
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        Value: 10.1093/molbev/msag035
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              Text: 2026 Mar 02
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