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Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity.

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Title: Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity.
Authors: Ostendorf BN; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA.; Department of Hematology, Oncology, and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine , Berlin, Germany.; German Cancer Consortium (DKTK), Partner Site Berlin, and German Cancer Research Center (DKFZ) , Heidelberg, Germany., Goldstein JG; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA.; Department of Hematology, Oncology, and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine , Berlin, Germany., Liu S; Department of Hematology, Oncology, and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine , Berlin, Germany., Gonsalves FC; Inspirna Inc. , New York, NY, USA., Bilanovic J; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA., Yuan M; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA., Kim JY; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA., Rouya C; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA., Tavazoie M; Inspirna Inc. , New York, NY, USA., Tavazoie SF; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA.
Source: The Journal of experimental medicine [J Exp Med] 2026 Apr 06; Vol. 223 (4). Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
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  Data: Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity.
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  Data: <searchLink fieldCode="AU" term="%22Ostendorf+BN%22">Ostendorf BN</searchLink>; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA.; Department of Hematology, Oncology, and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine , Berlin, Germany.; German Cancer Consortium (DKTK), Partner Site Berlin, and German Cancer Research Center (DKFZ) , Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Goldstein+JG%22">Goldstein JG</searchLink>; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA.; Department of Hematology, Oncology, and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine , Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Hematology, Oncology, and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine , Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Gonsalves+FC%22">Gonsalves FC</searchLink>; Inspirna Inc. , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bilanovic+J%22">Bilanovic J</searchLink>; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+M%22">Yuan M</searchLink>; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kim+JY%22">Kim JY</searchLink>; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rouya+C%22">Rouya C</searchLink>; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tavazoie+M%22">Tavazoie M</searchLink>; Inspirna Inc. , New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tavazoie+SF%22">Tavazoie SF</searchLink>; Laboratory of Systems Cancer Biology, The Rockefeller University , New York, NY, USA.
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  Data: <searchLink fieldCode="JN" term="%222985109R%22">The Journal of experimental medicine</searchLink> [J Exp Med] 2026 Apr 06; Vol. 223 (4). <i>Date of Electronic Publication: </i>2026 Feb 10.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Rockefeller+University+Press%22">Rockefeller University Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985109R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1540-9538 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200221007%22">00221007 </searchLink><i>NLM ISO Abbreviation: </i>J Exp Med <i>Subsets: </i>MEDLINE
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        Value: 10.1084/jem.20252290
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            – D: 06
              M: 04
              Text: 2026 Apr 06
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