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Statins halt polycystic liver disease by reprogramming metabolism and normalizing mitochondrial bioenergetics in cystic cholangiocytes.

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Title: Statins halt polycystic liver disease by reprogramming metabolism and normalizing mitochondrial bioenergetics in cystic cholangiocytes.
Authors: Markaide E; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain., Izquierdo-Sanchez L; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal., Olaizola I; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain., Urretabizkaia-Garmendia J; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain., Ruiz de Gauna M; Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain., Buqué X; Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain., Lasa-Elosegi I; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain., Lapitz A; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain., Bais T; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Val B; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain., Rodrigues PM; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain., Castro RE; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal., Perugorria MJ; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.; Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), San Sebastian, Spain., Bujanda L; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.; Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), San Sebastian, Spain., Gansevoort R; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Drenth JPH; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, The Netherlands; European Reference Network RARE-LIVER, Germany.; European Reference Network RARE-LIVER, Germany., Aspichueta P; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.; Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.; Biobizkaia Health Research Institute, Barakaldo, Spain., Banales JM; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.; Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain.
Source: Hepatology (Baltimore, Md.) [Hepatology] 2026 Feb 10. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE
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  Data: Statins halt polycystic liver disease by reprogramming metabolism and normalizing mitochondrial bioenergetics in cystic cholangiocytes.
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  Data: <searchLink fieldCode="AU" term="%22Markaide+E%22">Markaide E</searchLink>; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Izquierdo-Sanchez+L%22">Izquierdo-Sanchez L</searchLink>; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Olaizola+I%22">Olaizola I</searchLink>; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Urretabizkaia-Garmendia+J%22">Urretabizkaia-Garmendia J</searchLink>; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Ruiz+de+Gauna+M%22">Ruiz de Gauna M</searchLink>; Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.<br /><searchLink fieldCode="AU" term="%22Buqué+X%22">Buqué X</searchLink>; Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.<br /><searchLink fieldCode="AU" term="%22Lasa-Elosegi+I%22">Lasa-Elosegi I</searchLink>; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Lapitz+A%22">Lapitz A</searchLink>; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Bais+T%22">Bais T</searchLink>; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Val+B%22">Val B</searchLink>; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Rodrigues+PM%22">Rodrigues PM</searchLink>; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.<br /><searchLink fieldCode="AU" term="%22Castro+RE%22">Castro RE</searchLink>; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Perugorria+MJ%22">Perugorria MJ</searchLink>; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.; Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Bujanda+L%22">Bujanda L</searchLink>; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.; Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Gansevoort+R%22">Gansevoort R</searchLink>; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Drenth+JPH%22">Drenth JPH</searchLink>; Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, The Netherlands; European Reference Network RARE-LIVER, Germany.; European Reference Network RARE-LIVER, Germany.<br /><searchLink fieldCode="AU" term="%22Aspichueta+P%22">Aspichueta P</searchLink>; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.; Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.; Biobizkaia Health Research Institute, Barakaldo, Spain.<br /><searchLink fieldCode="AU" term="%22Banales+JM%22">Banales JM</searchLink>; Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute, Donostia University Hospital, San Sebastian, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, Madrid, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.; Department of Biochemistry and Genetics, School of Sciences, University of Navarra, Pamplona, Spain.
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  Data: <searchLink fieldCode="JN" term="%228302946%22">Hepatology (Baltimore, Md.)</searchLink> [Hepatology] 2026 Feb 10. <i>Date of Electronic Publication: </i>2026 Feb 10.
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              Text: 2026 Feb 10
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