Targeting NHEJ activates STING signaling through MYC degradation to boost antitumor immunity in SCLC.
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| Title: | Targeting NHEJ activates STING signaling through MYC degradation to boost antitumor immunity in SCLC. |
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| Authors: | Chakraborty S; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA., Elliott A; Department of Clinical and Translational Research, Caris Life Sciences Inc., Tempe, Arizona, USA., Sen U; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Coleman C; Tisch Cancer Institute, Mount Sinai, New York, NY, USA.; Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) core, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jethalia V; Tisch Cancer Institute, Mount Sinai, New York, NY, USA.; Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) core, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ventura K; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Fan CW; Tisch Cancer Institute, Mount Sinai, New York, NY, USA.; Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) core, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sritharan R; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Banerjee A; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Mahendravarman Y; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Vanderwalde A; Department of Clinical and Translational Research, Caris Life Sciences Inc., Tempe, Arizona, USA., Halmos B; Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY, USA., de Stanchina E; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Taniguchi H; Clinical Oncology Center, Nagasaki University Hospital, Nagasaki, Japan.; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan., Demircioglu D; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Tisch Cancer Institute, Mount Sinai, New York, NY, USA.; Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) core, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hasson D; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Tisch Cancer Institute, Mount Sinai, New York, NY, USA.; Tisch Cancer Institute Bioinformatics for Next Generation Sequencing (BiNGS) core, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sen T; Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA. triparna.sen@osumc.edu. |
| Source: | Nature communications [Nat Commun] 2026 Feb 10; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 10. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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