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Deciphering the molecular mechanism of sesamol in inflammatory bowel disease through an integrative computational and biological evaluation of the JAK1 signalling pathway.

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Title: Deciphering the molecular mechanism of sesamol in inflammatory bowel disease through an integrative computational and biological evaluation of the JAK1 signalling pathway.
Authors: Rajappan KP; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India., Benny S; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India., Radhakrishnan VV; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India., Presanna AT; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India., Pappachen LK; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India., Scotti MT; Departamento de Química, Centro de Ciências Exatas E da Natureza, Universidade Federal da Paraíba - Campus I, Cidade Universitária, João Pessoa, PB, CEP 58051-90, Brazil., Madhu K; Department of Pharmacology, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India., Mathew B; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India. bijomathew@aims.amrita.edu., Zachariah SM; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India. subinmaryzachariah@aims.amrita.edu.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Apr; Vol. 399 (7), pp. 10777-10799. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Rajappan+KP%22">Rajappan KP</searchLink>; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India.<br /><searchLink fieldCode="AU" term="%22Benny+S%22">Benny S</searchLink>; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India.<br /><searchLink fieldCode="AU" term="%22Radhakrishnan+VV%22">Radhakrishnan VV</searchLink>; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India.<br /><searchLink fieldCode="AU" term="%22Presanna+AT%22">Presanna AT</searchLink>; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India.<br /><searchLink fieldCode="AU" term="%22Pappachen+LK%22">Pappachen LK</searchLink>; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India.<br /><searchLink fieldCode="AU" term="%22Scotti+MT%22">Scotti MT</searchLink>; Departamento de Química, Centro de Ciências Exatas E da Natureza, Universidade Federal da Paraíba - Campus I, Cidade Universitária, João Pessoa, PB, CEP 58051-90, Brazil.<br /><searchLink fieldCode="AU" term="%22Madhu+K%22">Madhu K</searchLink>; Department of Pharmacology, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India.<br /><searchLink fieldCode="AU" term="%22Mathew+B%22">Mathew B</searchLink>; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India. bijomathew@aims.amrita.edu.<br /><searchLink fieldCode="AU" term="%22Zachariah+SM%22">Zachariah SM</searchLink>; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, 682041, India. subinmaryzachariah@aims.amrita.edu.
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