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Discovery of indolinone-based covalent ULK1 inhibitors that suppressed autophagy and induced apoptosis against colorectal carcinoma.

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Title: Discovery of indolinone-based covalent ULK1 inhibitors that suppressed autophagy and induced apoptosis against colorectal carcinoma.
Authors: Ye J; Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, 610041, China; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Wang D; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Pang H; Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, 610041, China; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Liu Q; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Pan Z; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Wang L; Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: wanglian8225@scu.edu.cn., Liu B; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., He G; Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, 610041, China; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: hegu@scu.edu.cn.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 Apr 05; Vol. 307, pp. 118633. Date of Electronic Publication: 2026 Jan 31.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery of indolinone-based covalent ULK1 inhibitors that suppressed autophagy and induced apoptosis against colorectal carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Ye+J%22">Ye J</searchLink>; Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, 610041, China; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.<br /><searchLink fieldCode="AU" term="%22Pang+H%22">Pang H</searchLink>; Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, 610041, China; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.<br /><searchLink fieldCode="AU" term="%22Liu+Q%22">Liu Q</searchLink>; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.<br /><searchLink fieldCode="AU" term="%22Pan+Z%22">Pan Z</searchLink>; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: wanglian8225@scu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Liu+B%22">Liu B</searchLink>; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.<br /><searchLink fieldCode="AU" term="%22He+G%22">He G</searchLink>; Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, 610041, China; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: hegu@scu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 Apr 05; Vol. 307, pp. 118633. <i>Date of Electronic Publication: </i>2026 Jan 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41672028
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.ejmech.2026.118633
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      – Code: eng
        Text: English
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        StartPage: 118633
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            – D: 05
              M: 04
              Text: 2026 Apr 05
              Type: published
              Y: 2026
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