Discovery of indolinone-based covalent ULK1 inhibitors that suppressed autophagy and induced apoptosis against colorectal carcinoma.
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| Title: | Discovery of indolinone-based covalent ULK1 inhibitors that suppressed autophagy and induced apoptosis against colorectal carcinoma. |
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| Authors: | Ye J; Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, 610041, China; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Wang D; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Pang H; Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, 610041, China; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Liu Q; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Pan Z; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Wang L; Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: wanglian8225@scu.edu.cn., Liu B; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., He G; Department of Dermatology & Venerology, West China Hospital, Sichuan University, Chengdu, 610041, China; Laboratory of Dermatology, Frontiers Science Center for Disease related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: hegu@scu.edu.cn. |
| Source: | European journal of medicinal chemistry [Eur J Med Chem] 2026 Apr 05; Vol. 307, pp. 118633. Date of Electronic Publication: 2026 Jan 31. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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