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In vivo visualization of cardiac extracellular adenosine dynamics and its pharmacological modulation in zebrafish heart failure models.

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Title: In vivo visualization of cardiac extracellular adenosine dynamics and its pharmacological modulation in zebrafish heart failure models.
Authors: Phurpa P; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan., Apolinario MEC; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan., Umeda R; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan.; Department of Advanced Medical Science, Faculty of Medicine, Oita University, Oita University, Yufu, Oita, 879-5593, Japan., Kume S; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan., Teranishi H; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan., Shimizu N; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, Oita University, Yufu, Oita, 879-5593, Japan., Shan M; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan., Shikano K; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan., Kurokawa T; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan., Hikida T; Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, Osaka, Japan., Hanada T; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, Oita University, Yufu, Oita, 879-5593, Japan., Li Y; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China., Hanada R; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan. reiko-hanada@oita-u.ac.jp.
Source: Scientific reports [Sci Rep] 2026 Feb 11; Vol. 16 (1). Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Phurpa+P%22">Phurpa P</searchLink>; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan.<br /><searchLink fieldCode="AU" term="%22Apolinario+MEC%22">Apolinario MEC</searchLink>; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan.<br /><searchLink fieldCode="AU" term="%22Umeda+R%22">Umeda R</searchLink>; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan.; Department of Advanced Medical Science, Faculty of Medicine, Oita University, Oita University, Yufu, Oita, 879-5593, Japan.<br /><searchLink fieldCode="AU" term="%22Kume+S%22">Kume S</searchLink>; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan.<br /><searchLink fieldCode="AU" term="%22Teranishi+H%22">Teranishi H</searchLink>; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan.<br /><searchLink fieldCode="AU" term="%22Shimizu+N%22">Shimizu N</searchLink>; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, Oita University, Yufu, Oita, 879-5593, Japan.<br /><searchLink fieldCode="AU" term="%22Shan+M%22">Shan M</searchLink>; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan.<br /><searchLink fieldCode="AU" term="%22Shikano+K%22">Shikano K</searchLink>; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan.<br /><searchLink fieldCode="AU" term="%22Kurokawa+T%22">Kurokawa T</searchLink>; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan.<br /><searchLink fieldCode="AU" term="%22Hikida+T%22">Hikida T</searchLink>; Laboratory for Advanced Brain Functions, Institute for Protein Research, Osaka University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Hanada+T%22">Hanada T</searchLink>; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, Oita University, Yufu, Oita, 879-5593, Japan.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; State Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Hanada+R%22">Hanada R</searchLink>; Department of Physiology, Faculty of Medicine, Oita University, Idaigaoka, Yufu, Oita, 879-5593, Japan. reiko-hanada@oita-u.ac.jp.
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