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Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours.

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Title: Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours.
Authors: Dörr J; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Gregor L; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Lacher SB; Institute of Molecular Immunology, TUM University Hospital, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.; Servier Deutschland, Munich, Germany., Oner A; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Sun Y; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Piseddu I; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.; Department of Medicine II, LMU University Hospital, Munich, Germany.; Gene Center, Department of Biochemistry, LMU Munich, Munich, Germany., Fertig L; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Spajic S; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Lesch S; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Michaelides S; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Seifert M; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Gottschlich A; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU, Munich, Germany., Samson N; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Majed L; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Briukhovetska D; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Simnica D; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Hartmann V; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Gabriel K; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Cohen S; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Boland GM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Gastrointestinal and Oncologic Surgery, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Andreu-Sanz D; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Carlini E; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Stock S; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, LMU, Munich, Germany., Holtermann A; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, LMU, Munich, Germany., Müller PJ; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Strzalkowski T; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Trefny MP; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany., Endres S; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, LMU, Munich, Germany.; Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Zentrum München-German Research Center for Environmental Health Neuherberg, Munich, Germany., Jenkins RW; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Böttcher JP; Institute of Molecular Immunology, TUM University Hospital, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.; M3 Research Center, University Hospital Tübingen, University of Tübingen, Tübingen, Germany.; Department of Experimental Immunology, Institute of Immunology, University of Tübingen, Tübingen, Germany., Kobold S; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany. Sebastian.kobold@med.uni-muenchen.de.; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, LMU, Munich, Germany. Sebastian.kobold@med.uni-muenchen.de.; Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Zentrum München-German Research Center for Environmental Health Neuherberg, Munich, Germany. Sebastian.kobold@med.uni-muenchen.de.; German Center for Lung Research (DZL), Partner Site Munich, Munich, Germany. Sebastian.kobold@med.uni-muenchen.de.
Source: Nature biomedical engineering [Nat Biomed Eng] 2026 Apr; Vol. 10 (4), pp. 697-710. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE
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  Data: Ablation of prostaglandin E<subscript>2</subscript> signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours.
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Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.; Department of Medicine III, LMU University Hospital, LMU, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Holtermann+A%22">Holtermann A</searchLink>; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, LMU, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+PJ%22">Müller PJ</searchLink>; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Strzalkowski+T%22">Strzalkowski T</searchLink>; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Trefny+MP%22">Trefny MP</searchLink>; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Endres+S%22">Endres S</searchLink>; Institute of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, LMU, Munich, Germany.; Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Zentrum München-German Research Center for Environmental Health Neuherberg, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jenkins+RW%22">Jenkins RW</searchLink>; Mass General Cancer Center, Krantz Family Center for Cancer Research, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Böttcher+JP%22">Böttcher JP</searchLink>; Institute of Molecular Immunology, TUM University Hospital, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany.; 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