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Systems-level transcriptomic analysis reveals synapse-related gene dysregulation in peripheral leukocytes of MDD patients.

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Title: Systems-level transcriptomic analysis reveals synapse-related gene dysregulation in peripheral leukocytes of MDD patients.
Authors: Adri AS; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil. annyadri@usp.br.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil. annyadri@usp.br., Nóbile AL; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil., de Albuquerque DG; Interunit Postgraduate Program in Bioinformatics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, SP, Brazil.; IDO'R Institute for Research, São Paulo, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil., Barcelos PM; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil., do Vale FYN; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil., Nava RG; Interunit Postgraduate Program in Bioinformatics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil., Correa YLG; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil., Schimke LF; Department of Medicine, Division of Molecular Medicine, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil., Onuchic LF; Department of Medicine, Division of Molecular Medicine, School of Medicine, University of São Paulo, São Paulo, SP, Brazil., Dalmolin R; Bioinformatics Multidisciplinary Environment, Federal University of Rio Grande Do Norte, Natal, RN, Brazil.; Department of Biochemistry, Federal University of Rio Grande Do Norte, Natal, RN, Brazil., Rezende RM; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Dias HD; Department of Medicine, Division of Molecular Medicine, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil., Filgueiras IS; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.; IDO'R Institute for Research, São Paulo, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil., Cabral-Marques O; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil. otavio.cmarques@usp.br.; Interunit Postgraduate Program in Bioinformatics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, SP, Brazil. otavio.cmarques@usp.br.; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil. otavio.cmarques@usp.br.; Bioinformatics Multidisciplinary Environment, Federal University of Rio Grande Do Norte, Natal, RN, Brazil. otavio.cmarques@usp.br.; Department of Medicine, Division of Molecular Medicine, School of Medicine, University of São Paulo, São Paulo, SP, Brazil. otavio.cmarques@usp.br.; IDO'R Institute for Research, São Paulo, Brazil. otavio.cmarques@usp.br.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil. otavio.cmarques@usp.br.; Department of Biochemistry, Federal University of Rio Grande Do Norte, Natal, RN, Brazil. otavio.cmarques@usp.br.
Source: Scientific reports [Sci Rep] 2026 Feb 11; Vol. 16 (1). Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: Systems-level transcriptomic analysis reveals synapse-related gene dysregulation in peripheral leukocytes of MDD patients.
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  Data: <searchLink fieldCode="AU" term="%22Adri+AS%22">Adri AS</searchLink>; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil. annyadri@usp.br.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil. annyadri@usp.br.<br /><searchLink fieldCode="AU" term="%22Nóbile+AL%22">Nóbile AL</searchLink>; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Albuquerque+DG%22">de Albuquerque DG</searchLink>; Interunit Postgraduate Program in Bioinformatics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, SP, Brazil.; IDO'R Institute for Research, São Paulo, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Barcelos+PM%22">Barcelos PM</searchLink>; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22do+Vale+FYN%22">do Vale FYN</searchLink>; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Nava+RG%22">Nava RG</searchLink>; Interunit Postgraduate Program in Bioinformatics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Correa+YLG%22">Correa YLG</searchLink>; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Schimke+LF%22">Schimke LF</searchLink>; Department of Medicine, Division of Molecular Medicine, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Onuchic+LF%22">Onuchic LF</searchLink>; Department of Medicine, Division of Molecular Medicine, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Dalmolin+R%22">Dalmolin R</searchLink>; Bioinformatics Multidisciplinary Environment, Federal University of Rio Grande Do Norte, Natal, RN, Brazil.; Department of Biochemistry, Federal University of Rio Grande Do Norte, Natal, RN, Brazil.<br /><searchLink fieldCode="AU" term="%22Rezende+RM%22">Rezende RM</searchLink>; Ann Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dias+HD%22">Dias HD</searchLink>; Department of Medicine, Division of Molecular Medicine, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Filgueiras+IS%22">Filgueiras IS</searchLink>; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil.; IDO'R Institute for Research, São Paulo, Brazil.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Cabral-Marques+O%22">Cabral-Marques O</searchLink>; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil. otavio.cmarques@usp.br.; Interunit Postgraduate Program in Bioinformatics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, SP, Brazil. otavio.cmarques@usp.br.; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil. otavio.cmarques@usp.br.; Bioinformatics Multidisciplinary Environment, Federal University of Rio Grande Do Norte, Natal, RN, Brazil. otavio.cmarques@usp.br.; Department of Medicine, Division of Molecular Medicine, School of Medicine, University of São Paulo, São Paulo, SP, Brazil. otavio.cmarques@usp.br.; IDO'R Institute for Research, São Paulo, Brazil. otavio.cmarques@usp.br.; Laboratory of Psychoneuroimmunology, Selye Lab, University of São Paulo School of Medicine, São Paulo, Brazil. otavio.cmarques@usp.br.; Department of Biochemistry, Federal University of Rio Grande Do Norte, Natal, RN, Brazil. otavio.cmarques@usp.br.
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