Prediction of Mutations and Outcome in Gastrointestinal Stromal Tumors with Deep Learning: A Multicenter, Multinational Study.
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| Title: | Prediction of Mutations and Outcome in Gastrointestinal Stromal Tumors with Deep Learning: A Multicenter, Multinational Study. |
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| Authors: | Bonetti A; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, 01307 Dresden, Germany., Le VL; Department of Data and Digital Health Institut Bergonié, Bordeaux, France.; INRIA center at University of Bordeaux, Talence, France.; Bordeaux Mathematics Institute (IMB), CNRS UMR 5251, University of Bordeaux, Talence, France., Carrero ZI; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, 01307 Dresden, Germany., Wolf F; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, 01307 Dresden, Germany., Gustav M; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, 01307 Dresden, Germany., Lam SW; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Vanhersecke L; Department of Biopathology Institut Bergonié, Bordeaux, France., Sobczuk P; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Le Loarer F; Institute of Oncology, BRIC U1312, INSERM, Université de Bordeaux, Institut Bergonié, 33000 Bordeaux, France.; Department of Biopathology Institut Bergonié, Bordeaux, France., Lenarcik M; Department of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, Warsaw, Poland.; Department of Cancer Pathology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Rutkowski P; Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., van Sabben JM; Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Steeghs N; Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Department of Medical Oncology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., van Boven H; Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Machado I; Department of Pathology, Instituto Valenciano de Oncología, Valencia. Spain.; Patologika Laboratory Hospital Quirón-Salud, Valencia. Spain.; Department of Pathology, University of Valencia. Spain.; CIBERONC(ISCIII), Madrid. Spain., Bagué S; Department of Pathology, Hospital de la Santa Creu i Sant Pau. Barcelona. Spain., Navarro S; Department of Pathology, University of Valencia. Spain.; INCLIVA,Valencia.; CIBERONC(ISCIII), Madrid. Spain., Medina-Ceballos E; Department of Pathology, University of Valencia. Spain., Agra C; Pathology Department HGU Gregorio Marañon (Madrid). Spain., Giner F; Department of Pathology, University of Valencia. Spain.; Department of Pathology, Hospital Universitari i Politècnic La Fe, Valencia. Spain., Tapia G; Department of Pathology. Hospital Universitari Germans Trias i Pujol. IGTP. Universitat Autònoma de Barcelona. Spain., Hernández-Gallego A; Department of Pathology. Hospital Universitari Germans Trias i Pujol. IGTP. Universitat Autònoma de Barcelona. Spain., Civantos Jubera G; Department of Pathology, Hospital Universitario Virgen del Rocío, Sevilla. Spain., Cuatrecasas M; Pathology Department. Hospital Clinic, Barcelona. University of Barcelona. Barcelona. Spain.; Liver and Digestive Diseases Biomedical Research Center Network (CIBERehd).; Carlosiii Health Institute. Madrid. Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). Barcelona, Spain., Lopez-Prades S; University of Barcelona, Faculty of Medicine. Spain.; Pathology Department, Hospital Clinic Barcelona. Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS). Barcelona, Spain., Perret RE; Department of Biopathology Institut Bergonié, Bordeaux, France.; Institute of Oncology, BRIC U1312, INSERM, Université de Bordeaux, Institut Bergonié, 33000 Bordeaux, France., Soubeyran I; Department of Biopathology Institut Bergonié, Bordeaux, France., Khalifa E; Department of Biopathology Institut Bergonié, Bordeaux, France., Blouin L; Department of Biopathology Institut Bergonié, Bordeaux, France., Wardelmann E; Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany., Meurgey A; Biopathology Department, Centre Léon Bérard, Unicancer, Lyon, France., Collini P; Department of Advanced Diagnostics - Soft Tissue Tumor Pathology Unit - Fondazione IRCCS Istituto Nazionale dei Tumori di Milano - Milan - Italy., Voloshin A; Gerhard-Domagk-Institute of Pathology, University Hospital Münster, Münster, Germany., Yatabe Y; Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan., Hirano H; Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan., Gronchi A; Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori and University of Milan, Milan, Italy., Nishida T; Department of Surgery, Japan Community Healthcare Organization Osaka Hospital, Osaka, Japan; Department of Surgery, National Cancer Center Hospital, Tokyo, Japan., Bouché O; Gastrointestinal Oncology Department. CHU Reims, Reims, France., Emile JF; Paris-Saclay University, Versailles SQY University, EA4340-BECCOH, Assistance Publique-Hôpitaux de Paris (AP-HP), Ambroise-Paré Hospital, Smart Imaging, Service de Pathologie, Boulogne, France., Ngo C; Department of Pathology, Gustave Roussy, 94800 Villejuif, France., Hohenberger P; Div. of Surgical Oncology, Mannheim University Medical Center, Medical Faculty Mannheim, University of Heidelberg, Germany., Cotarelo C; Institute of Pathology, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany., Jakob J; Department of Surgery, Sarcoma Unit, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Germany., Bovee JVMG; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Gelderblom H; Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands., Szumera-Cieckiewicz A; Biobank, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Jean-Denis M; Research and Innovation Department, Centre Léon Bérard, Unicancer, Lyon, France., Bollard J; Research and Innovation Department, Centre Léon Bérard, Unicancer, Lyon, France., Lassau N; Imaging Department. Gustave Roussy, 94800 Villejuif, France., Lecesne A; Department of Medical Oncology Gustave Roussy, 94800 Villejuif, France., Blay JY; Department of Medicine, Centre Leon Berard, & University Claude Bernard Lyon., Italiano A; Department of Medicine Institut Bergonié, Bordeaux, France.; Institute of Oncology, BRIC U1312, INSERM, Université de Bordeaux, Institut Bergonié, 33000 Bordeaux, France., Crombé A; Department of Oncologic Imaging, Gustave Roussy, 94800, Villejuif, France., Coindre JM; Institute of Oncology, BRIC U1312, INSERM, Université de Bordeaux, Institut Bergonié, 33000 Bordeaux, France.; Department of Biopathology Institut Bergonié, Bordeaux, France., Kather JN; Else Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, 01307 Dresden, Germany.; Department of Medicine I, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, 01307 Dresden, Germany.; Medical Oncology, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany.; Pathology & Data Analytics, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, United Kingdom. |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2026 Feb 03. Date of Electronic Publication: 2026 Feb 03. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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