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Integrative dual ctDNA 5mC/5hmC methylomics and clonal reconstruction infer tumor transcription and resistance phenotypes in metastatic prostate cancer.

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Title: Integrative dual ctDNA 5mC/5hmC methylomics and clonal reconstruction infer tumor transcription and resistance phenotypes in metastatic prostate cancer.
Authors: Li C; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Baj A; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Seo CCY; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Terrigino NT; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Bright JR; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Hennigan ST; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., King IM; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Wilkinson S; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Huang TT; Women's Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Trostel SY; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Figg WD; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Dahut WL; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Takeda DY; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Lee JM; Women's Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Karzai F; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA., Sowalsky AG; Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA.
Source: Research square [Res Sq] 2026 Feb 05. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrative dual ctDNA 5mC/5hmC methylomics and clonal reconstruction infer tumor transcription and resistance phenotypes in metastatic prostate cancer.
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