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Reproducible safety and efficacy of durvalumab with or without tremelimumab for hepatocellular carcinoma in clinical practice: Results of the DT-real study.

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Title: Reproducible safety and efficacy of durvalumab with or without tremelimumab for hepatocellular carcinoma in clinical practice: Results of the DT-real study.
Authors: Celsa C; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy., Pressiani T; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy., Nishida N; Department of Gastroenterology and Hepatology, Kindai University, Osaka, Japan., Chamseddine SM; Department of Gastrointestinal Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, TX, USA., Arvind A; Division of Digestive and Liver Diseases, University of Texas Southwestern, Dallas, Texas, USA., Li M; Division of Hematology/Oncology Helen Diller Family Comprehensive Cancer Center University of California, San Francisco San Francisco, California, USA., Fortuny M; Barcelona Clinic Liver Cancer (BCLC) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Liver Oncology Unit, Liver Unit, Hospital Clinic de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain., Khaled NB; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany., Iavarone M; Division of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; CRC 'A. M. and A. Migliavacca' Center for Liver Disease, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy., Toyoda H; Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Gifu, Japan., Rapposelli IG; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Casadei-Gardini A; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy., Vivaldi C; Unit of Medical Oncology 2, Azienda Ospedaliero- Universitaria Pisana, Pisa, Italy., Ulahannan S; Stephenson Cancer Center, University of Oklahoma/ Oklahoma City, Oklahoma, USA., Andanamala H; Stephenson Cancer Center, University of Oklahoma/ Oklahoma City, Oklahoma, USA., Scheiner B; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Pinter M; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Orlandi E; Department of Oncology-Hematology, Azienda USL of Piacenza, Piacenza, Italy., Fulgenzi CAM; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK., Manfredi GF; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy., Lombardi P; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.; Phase 1 Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy., D'Alessio A; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK., Stefanini B; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., Villani R; Liver Unit, Department of Medical and Surgical Sciences, University of Foggia, Italy., Ponziani FR; Liver Unit, CEMAD - Centro Malattie dell'Apparato Digerente, Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy., Stella L; Liver Unit, CEMAD - Centro Malattie dell'Apparato Digerente, Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy., Carminati O; Medical Oncology Unit, AUSL della Romagna, Rimini Hospital, Rimini, Italy., Ricci AD; Medical Oncology Unit, National Institute of Gastroenterology, IRCCS 'S. de Bellis' Research Hospital, Castellana Grotte, Italy., Gonzalez M; Barcelona Clinic Liver Cancer (BCLC) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain., Sparacino A; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy., Di Maria G; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy., Vaccaro M; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy., Cabibbo G; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy., Cammà C; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy., Reig M; Barcelona Clinic Liver Cancer (BCLC) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Liver Oncology Unit, Liver Unit, Hospital Clinic de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.; Barcelona University, Barcelona, Spain., Kelley RK; Division of Hematology/Oncology Helen Diller Family Comprehensive Cancer Center University of California, San Francisco San Francisco, California, USA., Singal AG; Division of Digestive and Liver Diseases, University of Texas Southwestern, Dallas, Texas, USA., Kaseb AO; Department of Gastrointestinal Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, TX, USA., Kudo M; Department of Gastroenterology and Hepatology, Kindai University, Osaka, Japan., Rimassa L; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy., Pinato DJ; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
Source: JHEP reports : innovation in hepatology [JHEP Rep] 2025 Nov 20; Vol. 8 (3), pp. 101685. Date of Electronic Publication: 2025 Nov 20 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101761237 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5559 (Electronic) Linking ISSN: 25895559 NLM ISO Abbreviation: JHEP Rep Subsets: In Process
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Reproducible safety and efficacy of durvalumab with or without tremelimumab for hepatocellular carcinoma in clinical practice: Results of the DT-real study.
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  Data: <searchLink fieldCode="AU" term="%22Celsa+C%22">Celsa C</searchLink>; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Pressiani+T%22">Pressiani T</searchLink>; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Nishida+N%22">Nishida N</searchLink>; Department of Gastroenterology and Hepatology, Kindai University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Chamseddine+SM%22">Chamseddine SM</searchLink>; Department of Gastrointestinal Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Arvind+A%22">Arvind A</searchLink>; Division of Digestive and Liver Diseases, University of Texas Southwestern, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Division of Hematology/Oncology Helen Diller Family Comprehensive Cancer Center University of California, San Francisco San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Fortuny+M%22">Fortuny M</searchLink>; Barcelona Clinic Liver Cancer (BCLC) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Liver Oncology Unit, Liver Unit, Hospital Clinic de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Khaled+NB%22">Khaled NB</searchLink>; Department of Medicine II, University Hospital, LMU Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Iavarone+M%22">Iavarone M</searchLink>; Division of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.; CRC 'A. M. and A. Migliavacca' Center for Liver Disease, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Toyoda+H%22">Toyoda H</searchLink>; Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Gifu, Japan.<br /><searchLink fieldCode="AU" term="%22Rapposelli+IG%22">Rapposelli IG</searchLink>; Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy.<br /><searchLink fieldCode="AU" term="%22Casadei-Gardini+A%22">Casadei-Gardini A</searchLink>; Department of Oncology, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Vivaldi+C%22">Vivaldi C</searchLink>; Unit of Medical Oncology 2, Azienda Ospedaliero- Universitaria Pisana, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Ulahannan+S%22">Ulahannan S</searchLink>; Stephenson Cancer Center, University of Oklahoma/ Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Andanamala+H%22">Andanamala H</searchLink>; Stephenson Cancer Center, University of Oklahoma/ Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Scheiner+B%22">Scheiner B</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Pinter+M%22">Pinter M</searchLink>; Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Orlandi+E%22">Orlandi E</searchLink>; Department of Oncology-Hematology, Azienda USL of Piacenza, Piacenza, Italy.<br /><searchLink fieldCode="AU" term="%22Fulgenzi+CAM%22">Fulgenzi CAM</searchLink>; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Manfredi+GF%22">Manfredi GF</searchLink>; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.<br /><searchLink fieldCode="AU" term="%22Lombardi+P%22">Lombardi P</searchLink>; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.; Phase 1 Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22D'Alessio+A%22">D'Alessio A</searchLink>; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Stefanini+B%22">Stefanini B</searchLink>; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Villani+R%22">Villani R</searchLink>; Liver Unit, Department of Medical and Surgical Sciences, University of Foggia, Italy.<br /><searchLink fieldCode="AU" term="%22Ponziani+FR%22">Ponziani FR</searchLink>; Liver Unit, CEMAD - Centro Malattie dell'Apparato Digerente, Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.; Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Stella+L%22">Stella L</searchLink>; Liver Unit, CEMAD - Centro Malattie dell'Apparato Digerente, Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Carminati+O%22">Carminati O</searchLink>; Medical Oncology Unit, AUSL della Romagna, Rimini Hospital, Rimini, Italy.<br /><searchLink fieldCode="AU" term="%22Ricci+AD%22">Ricci AD</searchLink>; Medical Oncology Unit, National Institute of Gastroenterology, IRCCS 'S. de Bellis' Research Hospital, Castellana Grotte, Italy.<br /><searchLink fieldCode="AU" term="%22Gonzalez+M%22">Gonzalez M</searchLink>; Barcelona Clinic Liver Cancer (BCLC) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Sparacino+A%22">Sparacino A</searchLink>; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Maria+G%22">Di Maria G</searchLink>; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Vaccaro+M%22">Vaccaro M</searchLink>; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Cabibbo+G%22">Cabibbo G</searchLink>; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Cammà+C%22">Cammà C</searchLink>; Gastroenterology and Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, University of Palermo, Palermo, Italy.<br /><searchLink fieldCode="AU" term="%22Reig+M%22">Reig M</searchLink>; Barcelona Clinic Liver Cancer (BCLC) Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.; Liver Oncology Unit, Liver Unit, Hospital Clinic de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.; Barcelona University, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Kelley+RK%22">Kelley RK</searchLink>; Division of Hematology/Oncology Helen Diller Family Comprehensive Cancer Center University of California, San Francisco San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Singal+AG%22">Singal AG</searchLink>; Division of Digestive and Liver Diseases, University of Texas Southwestern, Dallas, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Kaseb+AO%22">Kaseb AO</searchLink>; Department of Gastrointestinal Medical Oncology, M.D. Anderson Cancer Center, The University of Texas, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kudo+M%22">Kudo M</searchLink>; Department of Gastroenterology and Hepatology, Kindai University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Rimassa+L%22">Rimassa L</searchLink>; Medical Oncology and Hematology Unit, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pinato+DJ%22">Pinato DJ</searchLink>; Department of Surgery & Cancer, Imperial College London, Hammersmith Hospital, London, UK.; Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.
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