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EZH2 inhibition overcomes immunomodulatory drug resistance in multiple myeloma via a cereblon-dependent pathway.

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Title: EZH2 inhibition overcomes immunomodulatory drug resistance in multiple myeloma via a cereblon-dependent pathway.
Authors: Li Y; The Institute of Cancer Research., Wilson A; The Institute of Cancer Research., Chrisochoidou Y; The Institute of Cancer Research., Martin S; The Institute of Cancer Research., Bird S; The Institute of Cancer Research, London; The Royal Marsden Hospital NHS Foundation Trust., Morales S; The Institute of Cancer Research., Leiro M; The Institute of Cancer Research., Kozik Z; The Institute of Cancer Research., Crump NT; Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London., Roumeliotis TI; The Institute of Cancer Research., Choudhary J; The Institute of Cancer Research., Pawlyn C; The Institute of Cancer Research, London; The Royal Marsden Hospital NHS Foundation Trust. charlotte.pawlyn@icr.ac.uk.
Source: Haematologica [Haematologica] 2026 Feb 12. Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article
Journal Info: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: EZH2 inhibition overcomes immunomodulatory drug resistance in multiple myeloma via a cereblon-dependent pathway.
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  Data: <searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; The Institute of Cancer Research.<br /><searchLink fieldCode="AU" term="%22Wilson+A%22">Wilson A</searchLink>; The Institute of Cancer Research.<br /><searchLink fieldCode="AU" term="%22Chrisochoidou+Y%22">Chrisochoidou Y</searchLink>; The Institute of Cancer Research.<br /><searchLink fieldCode="AU" term="%22Martin+S%22">Martin S</searchLink>; The Institute of Cancer Research.<br /><searchLink fieldCode="AU" term="%22Bird+S%22">Bird S</searchLink>; The Institute of Cancer Research, London; The Royal Marsden Hospital NHS Foundation Trust.<br /><searchLink fieldCode="AU" term="%22Morales+S%22">Morales S</searchLink>; The Institute of Cancer Research.<br /><searchLink fieldCode="AU" term="%22Leiro+M%22">Leiro M</searchLink>; The Institute of Cancer Research.<br /><searchLink fieldCode="AU" term="%22Kozik+Z%22">Kozik Z</searchLink>; The Institute of Cancer Research.<br /><searchLink fieldCode="AU" term="%22Crump+NT%22">Crump NT</searchLink>; Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Department of Immunology and Inflammation, Imperial College London.<br /><searchLink fieldCode="AU" term="%22Roumeliotis+TI%22">Roumeliotis TI</searchLink>; The Institute of Cancer Research.<br /><searchLink fieldCode="AU" term="%22Choudhary+J%22">Choudhary J</searchLink>; The Institute of Cancer Research.<br /><searchLink fieldCode="AU" term="%22Pawlyn+C%22">Pawlyn C</searchLink>; The Institute of Cancer Research, London; The Royal Marsden Hospital NHS Foundation Trust. charlotte.pawlyn@icr.ac.uk.
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        Value: 10.3324/haematol.2025.288024
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      – Code: eng
        Text: English
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      – TitleFull: EZH2 inhibition overcomes immunomodulatory drug resistance in multiple myeloma via a cereblon-dependent pathway.
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              Text: 2026 Feb 12
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              Y: 2026
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