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Alpha-Actinin-3 Deficiency Links Genetic Susceptibility to Renal Fibrosis: Evidence From Hemodialysis Patients and Murine Models.

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Title: Alpha-Actinin-3 Deficiency Links Genetic Susceptibility to Renal Fibrosis: Evidence From Hemodialysis Patients and Murine Models.
Authors: Santos RB; Federal University of São Paulo, São Paulo, Brazil., Vieira HS; Laboratory of Nutrigenomics and Metabolism, Federal University of Pelotas, Pelotas, Brazil., Scheer AK; Laboratory of Nutrigenomics and Metabolism, Federal University of Pelotas, Pelotas, Brazil., Ribeiro LR; Catholic University of Pelotas, Pelotas, Brazil., Silva CF; Laboratory of Nutrigenomics and Metabolism, Federal University of Pelotas, Pelotas, Brazil., Orcy RB; Laboratory of Nutrigenomics and Metabolism, Federal University of Pelotas, Pelotas, Brazil., Schadock I; Department of Experimental Toxicology, German Federal Institute for Risk Assessment, Berlin, Germany., Budu A; Federal University of São Paulo, São Paulo, Brazil., Araujo RC; Federal University of São Paulo, São Paulo, Brazil., Schneider A; Laboratory of Nutrigenomics and Metabolism, Federal University of Pelotas, Pelotas, Brazil., Rodrigues AF; Max Delbrück Center for Molecular Medicine, Berlin, Germany.; German Center for Cardiovascular Research (DZHK), partner Site Berlin, Berlin, Germany., Bader M; Max Delbrück Center for Molecular Medicine, Berlin, Germany.; German Center for Cardiovascular Research (DZHK), partner Site Berlin, Berlin, Germany.; Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.; University of Lübeck, Institute for Biology, Lübeck, Germany., Böhlke M; Catholic University of Pelotas, Pelotas, Brazil., Barros CC; Laboratory of Nutrigenomics and Metabolism, Federal University of Pelotas, Pelotas, Brazil.; Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2026 Feb 28; Vol. 40 (4), pp. e71583.
Publication Type: Journal Article
Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE
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  Data: Alpha-Actinin-3 Deficiency Links Genetic Susceptibility to Renal Fibrosis: Evidence From Hemodialysis Patients and Murine Models.
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  Data: <searchLink fieldCode="AU" term="%22Santos+RB%22">Santos RB</searchLink>; Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Vieira+HS%22">Vieira HS</searchLink>; Laboratory of Nutrigenomics and Metabolism, Federal University of Pelotas, Pelotas, Brazil.<br /><searchLink fieldCode="AU" term="%22Scheer+AK%22">Scheer AK</searchLink>; Laboratory of Nutrigenomics and Metabolism, Federal University of Pelotas, Pelotas, Brazil.<br /><searchLink fieldCode="AU" term="%22Ribeiro+LR%22">Ribeiro LR</searchLink>; Catholic University of Pelotas, Pelotas, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+CF%22">Silva CF</searchLink>; Laboratory of Nutrigenomics and Metabolism, Federal University of Pelotas, Pelotas, Brazil.<br /><searchLink fieldCode="AU" term="%22Orcy+RB%22">Orcy RB</searchLink>; Laboratory of Nutrigenomics and Metabolism, Federal University of Pelotas, Pelotas, Brazil.<br /><searchLink fieldCode="AU" term="%22Schadock+I%22">Schadock I</searchLink>; Department of Experimental Toxicology, German Federal Institute for Risk Assessment, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Budu+A%22">Budu A</searchLink>; Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Araujo+RC%22">Araujo RC</searchLink>; Federal University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Schneider+A%22">Schneider A</searchLink>; Laboratory of Nutrigenomics and Metabolism, Federal University of Pelotas, Pelotas, Brazil.<br /><searchLink fieldCode="AU" term="%22Rodrigues+AF%22">Rodrigues AF</searchLink>; Max Delbrück Center for Molecular Medicine, Berlin, Germany.; German Center for Cardiovascular Research (DZHK), partner Site Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Bader+M%22">Bader M</searchLink>; Max Delbrück Center for Molecular Medicine, Berlin, Germany.; German Center for Cardiovascular Research (DZHK), partner Site Berlin, Berlin, Germany.; Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.; University of Lübeck, Institute for Biology, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Böhlke+M%22">Böhlke M</searchLink>; Catholic University of Pelotas, Pelotas, Brazil.<br /><searchLink fieldCode="AU" term="%22Barros+CC%22">Barros CC</searchLink>; Laboratory of Nutrigenomics and Metabolism, Federal University of Pelotas, Pelotas, Brazil.; Max Delbrück Center for Molecular Medicine, Berlin, Germany.
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