Discovery of KRAS-G12D degraders via exploration of various E3 ligases.
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| Title: | Discovery of KRAS-G12D degraders via exploration of various E3 ligases. |
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| Authors: | Yim H; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Song X; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Zhong Y; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Hu J; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Xiong Y; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address: yan.xiong@mssm.edu., Jin J; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address: jian.jin@mssm.edu. |
| Source: | European journal of medicinal chemistry [Eur J Med Chem] 2026 Apr 05; Vol. 307, pp. 118635. Date of Electronic Publication: 2026 Feb 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41679196 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Discovery of KRAS-G12D degraders via exploration of various E3 ligases. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Yim+H%22">Yim H</searchLink>; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.<br /><searchLink fieldCode="AU" term="%22Song+X%22">Song X</searchLink>; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.<br /><searchLink fieldCode="AU" term="%22Zhong+Y%22">Zhong Y</searchLink>; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.<br /><searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink>; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address: yan.xiong@mssm.edu.<br /><searchLink fieldCode="AU" term="%22Jin+J%22">Jin J</searchLink>; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address: jian.jin@mssm.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220420510%22">European journal of medicinal chemistry</searchLink> [Eur J Med Chem] 2026 Apr 05; Vol. 307, pp. 118635. <i>Date of Electronic Publication: </i>2026 Feb 03. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Editions+Scientifiques+Elsevier%22">Editions Scientifiques Elsevier </searchLink><i>Country of Publication: </i>France <i>NLM ID: </i>0420510 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1768-3254 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202235234%22">02235234 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41679196 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ejmech.2026.118635 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 118635 Titles: – TitleFull: Discovery of KRAS-G12D degraders via exploration of various E3 ligases. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yim H – PersonEntity: Name: NameFull: Song X – PersonEntity: Name: NameFull: Zhong Y – PersonEntity: Name: NameFull: Hu J – PersonEntity: Name: NameFull: Xiong Y – PersonEntity: Name: NameFull: Jin J IsPartOfRelationships: – BibEntity: Dates: – D: 05 M: 04 Text: 2026 Apr 05 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1768-3254 Numbering: – Type: volume Value: 307 Titles: – TitleFull: European journal of medicinal chemistry Type: main |
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