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Levels of migraine controls following International Headache Society (IHS) recommendations with eptinezumab: Effectiveness and tolerability in a 24-week, prospective multicenter study (the TACHIS study).

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Title: Levels of migraine controls following International Headache Society (IHS) recommendations with eptinezumab: Effectiveness and tolerability in a 24-week, prospective multicenter study (the TACHIS study).
Authors: Iannone LF; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy., Piella EM; Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy., Montisano DA; Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy., Fasano C; Neurologia, AOU Careggi, Florence, Italy., Sebastianelli G; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy., Coppola G; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy., Ferrandi D; SC Neurologia, Azienda Ospedaliero Universitaria SantiAntonio e Biagio, Alessandria, Italy., Lanni C; SC Neurologia, Azienda Ospedaliero Universitaria SantiAntonio e Biagio, Alessandria, Italy., Prudenzano MP; Clinica Neurologica 'L. Amaducci', Azienda Ospedaliero-Universitaria Consorziale di Bari, Bari, Italy., de Tommaso M; Neurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy., Merlo P; UO di Neurologia, Humanitas Gavazzeni, Bergamo, Italy., De Cesaris F; Headache center and Clinical pharmacology unit, AOU Careggi, Florence, Italy., Chiarugi A; Headache center and Clinical pharmacology unit, AOU Careggi, Florence, Italy., Munafò A; Headache center and Clinical pharmacology unit, AOU Careggi, Florence, Italy., Pistoia F; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Ornello R; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Doretti A; U.O. Neurologia, IRCCS Istituto Auxologico Italiano, San Luca, Milano, Italy., Grazzi L; Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy., Lo Castro F; Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico, Modena, Italy., De Icco R; Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy.; Headache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy., Vaghi G; Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy.; Headache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy., Avino G; SOC Neurologia, Ospedale di Prato, Prato, Italy., Romozzi M; Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy., Calabresi P; Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy., Battistini S; Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy., Rufa A; Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy., Albanese M; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Trimboli M; Azienda Ospedaliera-Universitaria 'Renato Dulbecco', Catanzaro, Italy., Carlucci G; Neurologia, AOU Careggi, Florence, Italy., Silvestro M; Headache Center, Department of Medical, Surgical,Neurological, Metabolic and Aging Sciences, Second University of Naples,Naples, Italy., Russo A; Headache Center, Department of Medical, Surgical,Neurological, Metabolic and Aging Sciences, Second University of Naples,Naples, Italy., Rainero I; Department of Neuroscience 'Rita Levi Montalcini', University of Turin, Turin, Italy., Valente MR; Dipartimento di Neuroscienze, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy., Fofi L; Headache and Neurosonology Unit, Fondazione Policlinico Campus Bio-Medico, Roma, Italy., Marcosano M; Headache and Neurosonology Unit, Fondazione Policlinico Campus Bio-Medico, Roma, Italy., Geppetti P; Department of Health Sciences, University of Florence, Florence, Italy., Altamura C; Headache and Neurosonology Unit, Fondazione Policlinico Campus Bio-Medico, Roma, Italy., Vernieri F; Headache and Neurosonology Unit, Fondazione Policlinico Campus Bio-Medico, Roma, Italy., Tassorelli C; Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy.; Headache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy., Sacco S; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Guerzoni S; Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico, Modena, Italy.
Corporate Authors: Italian Headache Registry (RICe) Study Group
Source: Cephalalgia : an international journal of headache [Cephalalgia] 2026 Feb; Vol. 46 (2), pp. 3331024251414659. Date of Electronic Publication: 2026 Feb 12.
Publication Type: Journal Article; Multicenter Study; Observational Study
Journal Info: Publisher: Country of Publication: England NLM ID: 8200710 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2982 (Electronic) Linking ISSN: 03331024 NLM ISO Abbreviation: Cephalalgia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Levels of migraine controls following International Headache Society (IHS) recommendations with eptinezumab: Effectiveness and tolerability in a 24-week, prospective multicenter study (the TACHIS study).
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Neurologia, IRCCS Istituto Auxologico Italiano, San Luca, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Grazzi+L%22">Grazzi L</searchLink>; Headache Center, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Lo+Castro+F%22">Lo Castro F</searchLink>; Digital and Predictive Medicine, Pharmacology, Clinical Metabolic Toxicology-Headache Center and Drug Abuse, Laboratory of Clinical Pharmacology and Pharmacogenomics, AOU Policlinico, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22De+Icco+R%22">De Icco R</searchLink>; Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy.; Headache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Vaghi+G%22">Vaghi G</searchLink>; Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy.; Headache Science and Neurorehabilitation Centre, IRCCS Mondino Foundation, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Avino+G%22">Avino G</searchLink>; SOC Neurologia, Ospedale di Prato, Prato, Italy.<br /><searchLink fieldCode="AU" term="%22Romozzi+M%22">Romozzi M</searchLink>; Fondazione Policlinico Universitario A. 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