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Targeted Lipid Nanoparticle Delivery of FAP-CAR mRNA Enables Potent In Vivo T-cell Engineering against Pancreatic Tumors.

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Title: Targeted Lipid Nanoparticle Delivery of FAP-CAR mRNA Enables Potent In Vivo T-cell Engineering against Pancreatic Tumors.
Authors: Bajbouj K; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania., Xiao Z; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania., Todd L; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania., Huang L; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania., Papp TE; Division of Infectious Diseases, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania., Halilovic F; Division of Infectious Diseases, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania., Ramani J; Division of Infectious Diseases, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania., Bao Y; Capstan Therapeutics, San Diego, California., Butcher M; Capstan Therapeutics, San Diego, California., Bot A; Capstan Therapeutics, San Diego, California., Aghajanian H; Capstan Therapeutics, San Diego, California., June CH; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania., Weissman D; Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, Pennsylvania., Parhiz H; Division of Infectious Diseases, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania.; Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, Pennsylvania., Albelda SM; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Puré E; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania.; Division of Infectious Diseases, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania.
Source: Cancer immunology research [Cancer Immunol Res] 2026 Apr 02; Vol. 14 (4), pp. 559-570.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE
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  Data: Targeted Lipid Nanoparticle Delivery of FAP-CAR mRNA Enables Potent In Vivo T-cell Engineering against Pancreatic Tumors.
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  Data: <searchLink fieldCode="AU" term="%22Bajbouj+K%22">Bajbouj K</searchLink>; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Xiao+Z%22">Xiao Z</searchLink>; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Todd+L%22">Todd L</searchLink>; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Huang+L%22">Huang L</searchLink>; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Papp+TE%22">Papp TE</searchLink>; Division of Infectious Diseases, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Halilovic+F%22">Halilovic F</searchLink>; Division of Infectious Diseases, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Ramani+J%22">Ramani J</searchLink>; Division of Infectious Diseases, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Bao+Y%22">Bao Y</searchLink>; Capstan Therapeutics, San Diego, California.<br /><searchLink fieldCode="AU" term="%22Butcher+M%22">Butcher M</searchLink>; Capstan Therapeutics, San Diego, California.<br /><searchLink fieldCode="AU" term="%22Bot+A%22">Bot A</searchLink>; Capstan Therapeutics, San Diego, California.<br /><searchLink fieldCode="AU" term="%22Aghajanian+H%22">Aghajanian H</searchLink>; Capstan Therapeutics, San Diego, California.<br /><searchLink fieldCode="AU" term="%22June+CH%22">June CH</searchLink>; Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Weissman+D%22">Weissman D</searchLink>; Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Parhiz+H%22">Parhiz H</searchLink>; Division of Infectious Diseases, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania.; Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Albelda+SM%22">Albelda SM</searchLink>; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Puré+E%22">Puré E</searchLink>; Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania.; Division of Infectious Diseases, Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania.
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  Data: <searchLink fieldCode="JN" term="%22101614637%22">Cancer immunology research</searchLink> [Cancer Immunol Res] 2026 Apr 02; Vol. 14 (4), pp. 559-570.
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