Safety, acceptability, and adherence to dapivirine vaginal ring and oral pre-exposure prophylaxis for HIV prevention in the second trimester of pregnancy: a multicountry, open-label, phase 3b randomised trial.

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Title: Safety, acceptability, and adherence to dapivirine vaginal ring and oral pre-exposure prophylaxis for HIV prevention in the second trimester of pregnancy: a multicountry, open-label, phase 3b randomised trial.
Authors: Mhlanga FG; University of Zimbabwe Clinical Trials Research Centre, Harare, Zimbabwe. Electronic address: fmhlanga@uz-ctrc.org., Szydlo DW; Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Center, Seattle, WA, USA., Mayo AJ; FHI 360, Durham, NC, USA., Bunge K; University of Pittsburgh and the Magee-Womens Research Institute, Pittsburgh, PA, USA., Fairlie L; Maternal and Child Health, Wits Reproductive Health and HIV Institute, Johannesburg, South Africa., Nakabiito C; Makerere University-Johns Hopkins University, Kampala, Uganda., Musara P; University of Zimbabwe Clinical Trials Research Centre, Harare, Zimbabwe., Mgodi NM; University of Zimbabwe Clinical Trials Research Centre, Harare, Zimbabwe., Dadabhai S; Johns Hopkins Research Project-Kamuzu University of Health Sciences, Blantyre, Malawi., Scheckter R; FHI 360, Durham, NC, USA., Anderson PL; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Marzinke MA; Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chappell C; University of Pittsburgh and the Magee-Womens Research Institute, Pittsburgh, PA, USA., Gadama LA; Johns Hopkins Research Project-Kamuzu University of Health Sciences, Blantyre, Malawi., Richardson BA; Department of Biostatistics and Department of Global Health, University of Washington, Seattle, WA, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Piper JM; DAIDS/NIAID/NIH/HHS, Rockville, ML, USA., Hillier SL; University of Pittsburgh and the Magee-Womens Research Institute, Pittsburgh, PA, USA.
Corporate Authors: MTN-042 DELIVER study team
Source: The lancet. HIV [Lancet HIV] 2026 Mar; Vol. 13 (3), pp. e176-e184. Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study
Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101645355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3018 (Electronic) Linking ISSN: 23523018 NLM ISO Abbreviation: Lancet HIV Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2352-3018
DOI:10.1016/S2352-3018(25)00307-8