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Does First-Line Treatment Impact Outcomes in Trisomy 21-Associated Infantile Epileptic Spasms Syndrome? A Multicenter North American Analysis.

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Title: Does First-Line Treatment Impact Outcomes in Trisomy 21-Associated Infantile Epileptic Spasms Syndrome? A Multicenter North American Analysis.
Authors: Cao V; Division of Neurology, BC Children's Hospital, University of British Columbia, Vancouver, Canada., Chiu MY; Department of Neurology, Boston Children's Hospital, Harvard University, Boston, Massachusetts., Chellamani H; Department of Neurology, Boston Children's Hospital, Harvard University, Boston, Massachusetts., Gupta N; Department of Neurology, Boston Children's Hospital, Harvard University, Boston, Massachusetts., Donatelli S; Department of Neurology, Boston Children's Hospital, Harvard University, Boston, Massachusetts., Pierce JG; Division of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Illinois., Lockrow J; Division of Pediatric Neurology, Seattle Children's Hospital, University of Washington, Seattle, Washington., Braschel M; BC Children's Hospital Research Institute, Vancouver, Canada., Whitney R; Division of Neurology, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada., Jones K; Division of Neurology, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada., Beatty CW; Division of Neurology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio., Mytinger JR; Division of Neurology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio., Datta AN; Division of Neurology, BC Children's Hospital, University of British Columbia, Vancouver, Canada. Electronic address: anita.datta@cw.bc.ca.
Source: Pediatric neurology [Pediatr Neurol] 2026 Apr; Vol. 177, pp. 130-136. Date of Electronic Publication: 2026 Jan 31.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Elsevier Science Publishing Country of Publication: United States NLM ID: 8508183 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5150 (Electronic) Linking ISSN: 08878994 NLM ISO Abbreviation: Pediatr Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Does First-Line Treatment Impact Outcomes in Trisomy 21-Associated Infantile Epileptic Spasms Syndrome? A Multicenter North American Analysis.
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  Data: <searchLink fieldCode="AU" term="%22Cao+V%22">Cao V</searchLink>; Division of Neurology, BC Children's Hospital, University of British Columbia, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Chiu+MY%22">Chiu MY</searchLink>; Department of Neurology, Boston Children's Hospital, Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Chellamani+H%22">Chellamani H</searchLink>; Department of Neurology, Boston Children's Hospital, Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Gupta+N%22">Gupta N</searchLink>; Department of Neurology, Boston Children's Hospital, Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Donatelli+S%22">Donatelli S</searchLink>; Department of Neurology, Boston Children's Hospital, Harvard University, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Pierce+JG%22">Pierce JG</searchLink>; Division of Neurology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University, Chicago, Illinois.<br /><searchLink fieldCode="AU" term="%22Lockrow+J%22">Lockrow J</searchLink>; Division of Pediatric Neurology, Seattle Children's Hospital, University of Washington, Seattle, Washington.<br /><searchLink fieldCode="AU" term="%22Braschel+M%22">Braschel M</searchLink>; BC Children's Hospital Research Institute, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Whitney+R%22">Whitney R</searchLink>; Division of Neurology, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Jones+K%22">Jones K</searchLink>; Division of Neurology, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Beatty+CW%22">Beatty CW</searchLink>; Division of Neurology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Mytinger+JR%22">Mytinger JR</searchLink>; Division of Neurology, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio.<br /><searchLink fieldCode="AU" term="%22Datta+AN%22">Datta AN</searchLink>; Division of Neurology, BC Children's Hospital, University of British Columbia, Vancouver, Canada. Electronic address: anita.datta@cw.bc.ca.
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  Data: <searchLink fieldCode="JN" term="%228508183%22">Pediatric neurology</searchLink> [Pediatr Neurol] 2026 Apr; Vol. 177, pp. 130-136. <i>Date of Electronic Publication: </i>2026 Jan 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Publishing%22">Elsevier Science Publishing </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8508183 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-5150 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208878994%22">08878994 </searchLink><i>NLM ISO Abbreviation: </i>Pediatr Neurol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.pediatrneurol.2026.01.018
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