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Timing matters: early administration of a high-affinity antibody targeting the tau repeat domain prevents aggregation in a mouse tauopathy model.

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Title: Timing matters: early administration of a high-affinity antibody targeting the tau repeat domain prevents aggregation in a mouse tauopathy model.
Authors: Penny LK; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; Scottish Biologics Facility, University of Aberdeen, Aberdeen, UK.; TauRx Therapeutics Management Ltd., Aberdeen, UK., Arastoo M; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK. mohammad.arastoo@abdn.ac.uk.; Scottish Biologics Facility, University of Aberdeen, Aberdeen, UK. mohammad.arastoo@abdn.ac.uk., Lofthouse R; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; Scottish Biologics Facility, University of Aberdeen, Aberdeen, UK., Abdallah A; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; Scottish Biologics Facility, University of Aberdeen, Aberdeen, UK., Imoesi PI; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK., Schwab K; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK., Shiells H; TauRx Therapeutics Management Ltd., Aberdeen, UK., Melis V; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK., Riedel G; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK., Harrington CR; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; GT Diagnostics (UK) Ltd., Aberdeen, UK.; TauRx Therapeutics Management Ltd., Aberdeen, UK., Wischik CM; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; GT Diagnostics (UK) Ltd., Aberdeen, UK.; TauRx Therapeutics Management Ltd., Aberdeen, UK., Porter A; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; Scottish Biologics Facility, University of Aberdeen, Aberdeen, UK., Palliyil S; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; Scottish Biologics Facility, University of Aberdeen, Aberdeen, UK.
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2026 Feb 14; Vol. 18 (1). Date of Electronic Publication: 2026 Feb 14.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Timing matters: early administration of a high-affinity antibody targeting the tau repeat domain prevents aggregation in a mouse tauopathy model.
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  Data: <searchLink fieldCode="AU" term="%22Penny+LK%22">Penny LK</searchLink>; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; Scottish Biologics Facility, University of Aberdeen, Aberdeen, UK.; TauRx Therapeutics Management Ltd., Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Arastoo+M%22">Arastoo M</searchLink>; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK. mohammad.arastoo@abdn.ac.uk.; Scottish Biologics Facility, University of Aberdeen, Aberdeen, UK. mohammad.arastoo@abdn.ac.uk.<br /><searchLink fieldCode="AU" term="%22Lofthouse+R%22">Lofthouse R</searchLink>; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; Scottish Biologics Facility, University of Aberdeen, Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Abdallah+A%22">Abdallah A</searchLink>; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; Scottish Biologics Facility, University of Aberdeen, Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Imoesi+PI%22">Imoesi PI</searchLink>; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Schwab+K%22">Schwab K</searchLink>; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Shiells+H%22">Shiells H</searchLink>; TauRx Therapeutics Management Ltd., Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Melis+V%22">Melis V</searchLink>; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Riedel+G%22">Riedel G</searchLink>; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Harrington+CR%22">Harrington CR</searchLink>; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; GT Diagnostics (UK) Ltd., Aberdeen, UK.; TauRx Therapeutics Management Ltd., Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Wischik+CM%22">Wischik CM</searchLink>; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; GT Diagnostics (UK) Ltd., Aberdeen, UK.; TauRx Therapeutics Management Ltd., Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Porter+A%22">Porter A</searchLink>; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; Scottish Biologics Facility, University of Aberdeen, Aberdeen, UK.<br /><searchLink fieldCode="AU" term="%22Palliyil+S%22">Palliyil S</searchLink>; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.; Scottish Biologics Facility, University of Aberdeen, Aberdeen, UK.
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  Data: <searchLink fieldCode="JN" term="%22101511643%22">Alzheimer's research & therapy</searchLink> [Alzheimers Res Ther] 2026 Feb 14; Vol. 18 (1). <i>Date of Electronic Publication: </i>2026 Feb 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central+Ltd%22">BioMed Central Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101511643 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1758-9193 (Electronic) <i>NLM ISO Abbreviation: </i>Alzheimers Res Ther <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41691301
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        Value: 10.1186/s13195-026-01985-x
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              Text: 2026 Feb 14
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