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ALDH2 activation protects against mutant TOMM40-mediated mitochondrial dysfunction and neurodegeneration in Alzheimer's disease.

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Title: ALDH2 activation protects against mutant TOMM40-mediated mitochondrial dysfunction and neurodegeneration in Alzheimer's disease.
Authors: Chen YC; Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Dementia Center, Taoyuan Chang Gung Memorial Hospital, Taoyuan, 33378, Taiwan., Chiu TJ; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan., Wu YY; Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Dementia Center, Taoyuan Chang Gung Memorial Hospital, Taoyuan, 33378, Taiwan., Wang YT; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan., Wu KH; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan., Yeh TH; Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan., Hsieh YJ; Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Chen WS; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan., Chiu CC; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan; R&D Center of Biochemical Engineering Technology, Ming Chi University of Technology, New Taipei City, Taiwan; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, Taiwan. Electronic address: ccchei@mail.cgu.edu.tw.
Source: Life sciences [Life Sci] 2026 Apr 15; Vol. 391, pp. 124274. Date of Electronic Publication: 2026 Feb 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ALDH2 activation protects against mutant TOMM40-mediated mitochondrial dysfunction and neurodegeneration in Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Dementia Center, Taoyuan Chang Gung Memorial Hospital, Taoyuan, 33378, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+TJ%22">Chiu TJ</searchLink>; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+YY%22">Wu YY</searchLink>; Department of Neurology, Chang Gung Memorial Hospital Linkou Medical Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Dementia Center, Taoyuan Chang Gung Memorial Hospital, Taoyuan, 33378, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+YT%22">Wang YT</searchLink>; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+KH%22">Wu KH</searchLink>; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+TH%22">Yeh TH</searchLink>; Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsieh+YJ%22">Hsieh YJ</searchLink>; Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+WS%22">Chen WS</searchLink>; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiu+CC%22">Chiu CC</searchLink>; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan; R&D Center of Biochemical Engineering Technology, Ming Chi University of Technology, New Taipei City, Taiwan; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, Taiwan. Electronic address: ccchei@mail.cgu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%220375521%22">Life sciences</searchLink> [Life Sci] 2026 Apr 15; Vol. 391, pp. 124274. <i>Date of Electronic Publication: </i>2026 Feb 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0375521 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0631 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200243205%22">00243205 </searchLink><i>NLM ISO Abbreviation: </i>Life Sci <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.lfs.2026.124274
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        Text: English
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              Text: 2026 Apr 15
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