Flexibility in the Modelling of Comparative Effectiveness in the Absence of Head-to-Head Comparisons in the NICE Single Technology Appraisal of Fenfluramine for Treating Seizures Associated with Lennox-Gastaut Syndrome: An External Assessment Group Perspective.

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Title: Flexibility in the Modelling of Comparative Effectiveness in the Absence of Head-to-Head Comparisons in the NICE Single Technology Appraisal of Fenfluramine for Treating Seizures Associated with Lennox-Gastaut Syndrome: An External Assessment Group Perspective.
Authors: Fernández Coves A; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands., Scholte M; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands.; Departments of IQ Health and Radiology, Radboudumc, Nijmegen, The Netherlands., Wolff R; Kleijnen Systematic Reviews Limited, York, UK., Perry M; Kleijnen Systematic Reviews Limited, York, UK., Sugden B; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands., Chen J; Kleijnen Systematic Reviews Limited, York, UK., Armstrong N; Kleijnen Systematic Reviews Limited, York, UK., Joore M; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands., Witlox W; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands. willem.witlox@mumc.nl.
Source: PharmacoEconomics [Pharmacoeconomics] 2026 Jun; Vol. 44 (6), pp. 647-652. Date of Electronic Publication: 2026 Feb 16.
Publication Type: Journal Article
Journal Info: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 9212404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-2027 (Electronic) Linking ISSN: 11707690 NLM ISO Abbreviation: Pharmacoeconomics Subsets: MEDLINE; In Process
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  Data: Flexibility in the Modelling of Comparative Effectiveness in the Absence of Head-to-Head Comparisons in the NICE Single Technology Appraisal of Fenfluramine for Treating Seizures Associated with Lennox-Gastaut Syndrome: An External Assessment Group Perspective.
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  Data: <searchLink fieldCode="AU" term="%22Fernández+Coves+A%22">Fernández Coves A</searchLink>; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Scholte+M%22">Scholte M</searchLink>; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands.; Departments of IQ Health and Radiology, Radboudumc, Nijmegen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wolff+R%22">Wolff R</searchLink>; Kleijnen Systematic Reviews Limited, York, UK.<br /><searchLink fieldCode="AU" term="%22Perry+M%22">Perry M</searchLink>; Kleijnen Systematic Reviews Limited, York, UK.<br /><searchLink fieldCode="AU" term="%22Sugden+B%22">Sugden B</searchLink>; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Kleijnen Systematic Reviews Limited, York, UK.<br /><searchLink fieldCode="AU" term="%22Armstrong+N%22">Armstrong N</searchLink>; Kleijnen Systematic Reviews Limited, York, UK.<br /><searchLink fieldCode="AU" term="%22Joore+M%22">Joore M</searchLink>; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Witlox+W%22">Witlox W</searchLink>; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre+ (MUMC+), Maastricht, The Netherlands. willem.witlox@mumc.nl.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Adis%2C+Springer+International%22">Adis, Springer International </searchLink><i>Country of Publication: </i>New Zealand <i>NLM ID: </i>9212404 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1179-2027 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2211707690%22">11707690 </searchLink><i>NLM ISO Abbreviation: </i>Pharmacoeconomics <i>Subsets: </i>MEDLINE; In Process
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