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Prophylactic Treatment of Patent Ductus Arteriosus With Acetaminophen: A Randomized Clinical Trial.

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Title: Prophylactic Treatment of Patent Ductus Arteriosus With Acetaminophen: A Randomized Clinical Trial.
Authors: Rozé JC; Department of Neonatal Medicine, Nantes University Hospital, Inserm, Centre d'Investigation Clinique 1413, Nantes, France., Cambonie G; Department of Neonatal Medicine, Montpellier University Hospital, Montpellier, France., Flamant C; Department of Neonatal Medicine, Nantes University Hospital, Inserm, Centre d'Investigation Clinique 1413, Nantes, France., Patkaï J; Department of Neonatal Medicine, Cochin Port-Royal Hospital, Fédération Hospitalo-Universitaire PREMA, Assistance Publique-Hôpitaux de Paris Centre, Paris, France., Mühlbacher T; Newborn Research, Department of Neonatology, University Hospital and University of Zürich, Zürich, Switzerland., Gascoin G; Neonatal Intensive Care, University Hospital, Toulouse, France., Rideau Batista Novais A; Department of Neonatology, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France., Tauzin M; Neonatal Intensive Care Unit, Centre Hospitalier Intercommunal de Créteil, Créteil, France., Le Duc K; Department of Neonatology, Lille University Hospital, Lille, France., Beuchée A; Neonatology, University of Rennes, CHU Rennes, Inserm, LTSI-UMR 1099, Rennes, France., Joye S; Department of Mother-Woman-Child, Clinic of Neonatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Babacheva E; Second Department of Neonatology and Neonatal Intensive Care Unit, General Hospital of Papageorgiou, Aristotle University of Thessaloniki, Thessaloniki, Greece., Bouissou A; Department of Neonatology, CHU Tours, Tours University, Tours, France., Ligi I; Department of Neonatalogy, Assistance Publique Hôpitaux de Marseille, Marseille, France., Tammela O; Department of Neonatalogy, Tampere University, Tampere, Finland., Plourde M; Department of Neonatal Medicine, Angers University Hospital, Angers, France., Dempsey E; Department of Paediatrics and Child Health, INFANT Centre, University College Cork, Cork, Ireland., Tosello B; Department of Neonatology, North Hospital, Assistance Publique des Hôpitaux de Marseille, Marseille, France., Nguyen K; Department of Neonatology and Neonatal Reanimation, Hospices Civils de Lyon, Hôpital Femme Mère Enfant, Bron, France., Vincent M; Department of Neonatology, Hospices Civils de Lyon, Hôpital de la Croix Rousse, Lyon, France., Andresson P; Department of Neonatology, East Tallinn Central Hospital, Tallinn, Estonia., Binder C; Division of Neonatology, Department of Pediatrics, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Kruse C; Department of Pediatrics, Rigshospitalet, Copenhagen, Denmark., Barcos Munoz F; Neonatal Intensive Care Unit, University Hospital of Geneva, Geneva, Switzerland., Kuhn P; Department of Neonatal Medicine, University Hospital of Strasbourg, University of Strasbourg, Strasbourg, France., Proença E; Department of Neonatology, Centro Hospitalar Universitário de Santo António, Porto, Portugal., Bartocci M; Department of Neonatology, Karolinska University Hospital, Stockholm, Sweden., Kermorvant-Duchemin E; Pédiatrie et Réanimation Néonatales, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France., Nellis G; Neonatal Unit, Tartu University Hospital, Children's Clinic, Tartu, Estonia., Lumia M; New Children's Hospital, Clinical Trial Unit and Department of Neonatology, Helsinki University Hospital, Helsinki, Finland., Giapros V; Neonatal Intensive Care Unit, School of Medicine, University of Ioannina, Ioannina, Greece., Rigo V; Centre Hospitalier Universitaire de Liège, Liège, Belgium., Sankilampi U; Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland., Mendes da Graça A; Division of Neonatology, Hospital de Santa Maria, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Rønnestad A; Department of Neonatal Intensive Care, Oslo University Hospital, Oslo, Norway., Soukka H; Department of Pediatrics and Adolescent Medicine, University Hospital of Turku and Turku University, Turku, Finland., Mondì V; Neonatology and Neonatal Intensive Care Unit, Policlinico Casilino, Rome, Italy., Aikio O; Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, and Research Unit of Clinical Medicine and MRC Oulu, University of Oulu, Oulu, Finland., Torre-Monmany N; Department of Neonatology, Parc Taulí University Hospital, Sabadell, Barcelona., Rüegger C; Newborn Research, Department of Neonatology, University Hospital and University of Zürich, Zürich, Switzerland., Baud O; Department of Neonatal Medicine, Cochin Port-Royal Hospital, Fédération Hospitalo-Universitaire PREMA, Assistance Publique-Hôpitaux de Paris Centre, Paris, France.; Neonatal Intensive Care Unit, University Hospital of Geneva, Geneva, Switzerland., Zeitlin J; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research for Epidemiology and Statistics (CRESS-UMR1153) Obstetrical, Perinatal Paediatric and Life Course Epidemiology (OPPaLE) Team, Paris, France., Morgan AS; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research for Epidemiology and Statistics (CRESS-UMR1153) Obstetrical, Perinatal Paediatric and Life Course Epidemiology (OPPaLE) Team, Paris, France.; Department of Neonatology, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK., Baruteau AE; Department of Pediatric Cardiology and Pediatric Cardiac Surgery, Fédération Hospitalo-Universitaire PRECICARE, Nantes Université, CHU Nantes, Nantes, France., Ancel PY; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research for Epidemiology and Statistics (CRESS-UMR1153) Obstetrical, Perinatal Paediatric and Life Course Epidemiology (OPPaLE) Team, Paris, France., Carbajal R; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research for Epidemiology and Statistics (CRESS-UMR1153) Obstetrical, Perinatal Paediatric and Life Course Epidemiology (OPPaLE) Team, Paris, France.; Paediatric Emergency Department, Hôpital Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Paris, France., Bouazza N; Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, URP7323, Université Paris Cité, Paris, France., Diallo A; Clinical Trial Safety and Public Health, ANRS, Emerging Infectious Diseases, Paris, France.; Clinical Research Safety Department, Inserm, Paris, France., Levoyer L; Clinical Trial Safety and Public Health, ANRS, Emerging Infectious Diseases, Paris, France.; Clinical Research Safety Department, Inserm, Paris, France., Kemper R; Global Foundation for the Care of Newborn Infants, Munich, Germany., Hallman M; Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, and Research Unit of Clinical Medicine and MRC Oulu, University of Oulu, Oulu, Finland., Alberti C; Université Paris Cité, Unité d'épidémiologie clinique, Hôpital Robert Debré, Partners FCRIN, Assistance Publique-Hôpitaux de Paris, Inserm, Centre d'Investigation Clinique 1426, ECEVE, Paris, France., Ursino M; Université Paris Cité, Unité d'épidémiologie clinique, Hôpital Robert Debré, Partners FCRIN, Assistance Publique-Hôpitaux de Paris, Inserm, Centre d'Investigation Clinique 1426, ECEVE, Paris, France.; Inserm, Université Paris Cité, Inria, HeKA, Paris, France.
Corporate Authors: TREOCAPA Study Group
Source: JAMA pediatrics [JAMA Pediatr] 2026 Apr 01; Vol. 180 (4), pp. 374-383.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589544 Publication Model: Print Cited Medium: Internet ISSN: 2168-6211 (Electronic) Linking ISSN: 21686203 NLM ISO Abbreviation: JAMA Pediatr Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Prophylactic Treatment of Patent Ductus Arteriosus With Acetaminophen: A Randomized Clinical Trial.
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  Data: <searchLink fieldCode="AU" term="%22Rozé+JC%22">Rozé JC</searchLink>; Department of Neonatal Medicine, Nantes University Hospital, Inserm, Centre d'Investigation Clinique 1413, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Cambonie+G%22">Cambonie G</searchLink>; Department of Neonatal Medicine, Montpellier University Hospital, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Flamant+C%22">Flamant C</searchLink>; Department of Neonatal Medicine, Nantes University Hospital, Inserm, Centre d'Investigation Clinique 1413, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Patkaï+J%22">Patkaï J</searchLink>; Department of Neonatal Medicine, Cochin Port-Royal Hospital, Fédération Hospitalo-Universitaire PREMA, Assistance Publique-Hôpitaux de Paris Centre, Paris, France.<br /><searchLink fieldCode="AU" term="%22Mühlbacher+T%22">Mühlbacher T</searchLink>; Newborn Research, Department of Neonatology, University Hospital and University of Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gascoin+G%22">Gascoin G</searchLink>; Neonatal Intensive Care, University Hospital, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Rideau+Batista+Novais+A%22">Rideau Batista Novais A</searchLink>; Department of Neonatology, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Tauzin+M%22">Tauzin M</searchLink>; Neonatal Intensive Care Unit, Centre Hospitalier Intercommunal de Créteil, Créteil, France.<br /><searchLink fieldCode="AU" term="%22Le+Duc+K%22">Le Duc K</searchLink>; Department of Neonatology, Lille University Hospital, Lille, France.<br /><searchLink fieldCode="AU" term="%22Beuchée+A%22">Beuchée A</searchLink>; Neonatology, University of Rennes, CHU Rennes, Inserm, LTSI-UMR 1099, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Joye+S%22">Joye S</searchLink>; Department of Mother-Woman-Child, Clinic of Neonatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Babacheva+E%22">Babacheva E</searchLink>; Second Department of Neonatology and Neonatal Intensive Care Unit, General Hospital of Papageorgiou, Aristotle University of Thessaloniki, Thessaloniki, Greece.<br /><searchLink fieldCode="AU" term="%22Bouissou+A%22">Bouissou A</searchLink>; Department of Neonatology, CHU Tours, Tours University, Tours, France.<br /><searchLink fieldCode="AU" term="%22Ligi+I%22">Ligi I</searchLink>; Department of Neonatalogy, Assistance Publique Hôpitaux de Marseille, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Tammela+O%22">Tammela O</searchLink>; Department of Neonatalogy, Tampere University, Tampere, Finland.<br /><searchLink fieldCode="AU" term="%22Plourde+M%22">Plourde M</searchLink>; Department of Neonatal Medicine, Angers University Hospital, Angers, France.<br /><searchLink fieldCode="AU" term="%22Dempsey+E%22">Dempsey E</searchLink>; Department of Paediatrics and Child Health, INFANT Centre, University College Cork, Cork, Ireland.<br /><searchLink fieldCode="AU" term="%22Tosello+B%22">Tosello B</searchLink>; 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Neonatal Intensive Care Unit, University Hospital of Geneva, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zeitlin+J%22">Zeitlin J</searchLink>; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research for Epidemiology and Statistics (CRESS-UMR1153) Obstetrical, Perinatal Paediatric and Life Course Epidemiology (OPPaLE) Team, Paris, France.<br /><searchLink fieldCode="AU" term="%22Morgan+AS%22">Morgan AS</searchLink>; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research for Epidemiology and Statistics (CRESS-UMR1153) Obstetrical, Perinatal Paediatric and Life Course Epidemiology (OPPaLE) Team, Paris, France.; Department of Neonatology, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Baruteau+AE%22">Baruteau AE</searchLink>; Department of Pediatric Cardiology and Pediatric Cardiac Surgery, Fédération Hospitalo-Universitaire PRECICARE, Nantes Université, CHU Nantes, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Ancel+PY%22">Ancel PY</searchLink>; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research for Epidemiology and Statistics (CRESS-UMR1153) Obstetrical, Perinatal Paediatric and Life Course Epidemiology (OPPaLE) Team, Paris, France.<br /><searchLink fieldCode="AU" term="%22Carbajal+R%22">Carbajal R</searchLink>; Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Centre for Research for Epidemiology and Statistics (CRESS-UMR1153) Obstetrical, Perinatal Paediatric and Life Course Epidemiology (OPPaLE) Team, Paris, France.; Paediatric Emergency Department, Hôpital Armand Trousseau, Assistance Publique-Hôpitaux de Paris, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bouazza+N%22">Bouazza N</searchLink>; Pharmacologie et évaluations des thérapeutiques chez l'enfant et la femme enceinte, URP7323, Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Diallo+A%22">Diallo A</searchLink>; Clinical Trial Safety and Public Health, ANRS, Emerging Infectious Diseases, Paris, France.; Clinical Research Safety Department, Inserm, Paris, France.<br /><searchLink fieldCode="AU" term="%22Levoyer+L%22">Levoyer L</searchLink>; Clinical Trial Safety and Public Health, ANRS, Emerging Infectious Diseases, Paris, France.; Clinical Research Safety Department, Inserm, Paris, France.<br /><searchLink fieldCode="AU" term="%22Kemper+R%22">Kemper R</searchLink>; Global Foundation for the Care of Newborn Infants, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hallman+M%22">Hallman M</searchLink>; Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, and Research Unit of Clinical Medicine and MRC Oulu, University of Oulu, Oulu, Finland.<br /><searchLink fieldCode="AU" term="%22Alberti+C%22">Alberti C</searchLink>; Université Paris Cité, Unité d'épidémiologie clinique, Hôpital Robert Debré, Partners FCRIN, Assistance Publique-Hôpitaux de Paris, Inserm, Centre d'Investigation Clinique 1426, ECEVE, Paris, France.<br /><searchLink fieldCode="AU" term="%22Ursino+M%22">Ursino M</searchLink>; Université Paris Cité, Unité d'épidémiologie clinique, Hôpital Robert Debré, Partners FCRIN, Assistance Publique-Hôpitaux de Paris, Inserm, Centre d'Investigation Clinique 1426, ECEVE, Paris, France.; Inserm, Université Paris Cité, Inria, HeKA, Paris, France.
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            NameFull: Aikio O
      – PersonEntity:
          Name:
            NameFull: Torre-Monmany N
      – PersonEntity:
          Name:
            NameFull: Rüegger C
      – PersonEntity:
          Name:
            NameFull: Baud O
      – PersonEntity:
          Name:
            NameFull: Zeitlin J
      – PersonEntity:
          Name:
            NameFull: Morgan AS
      – PersonEntity:
          Name:
            NameFull: Baruteau AE
      – PersonEntity:
          Name:
            NameFull: Ancel PY
      – PersonEntity:
          Name:
            NameFull: Carbajal R
      – PersonEntity:
          Name:
            NameFull: Bouazza N
      – PersonEntity:
          Name:
            NameFull: Diallo A
      – PersonEntity:
          Name:
            NameFull: Levoyer L
      – PersonEntity:
          Name:
            NameFull: Kemper R
      – PersonEntity:
          Name:
            NameFull: Hallman M
      – PersonEntity:
          Name:
            NameFull: Alberti C
      – PersonEntity:
          Name:
            NameFull: Ursino M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: 2026 Apr 01
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2168-6211
          Numbering:
            – Type: volume
              Value: 180
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: JAMA pediatrics
              Type: main
ResultId 1