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Spatial characterisation of TREM2 expression in actively demyelinating multiple sclerosis lesions supports its key roles in lipid metabolic pathways.

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Title: Spatial characterisation of TREM2 expression in actively demyelinating multiple sclerosis lesions supports its key roles in lipid metabolic pathways.
Authors: A Aguirre Candia Y; Charles Perkins Centre, Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Aladyeva E; Division of Neurogenetics, Neurobiology of Aging and Resilience Centre, Ohio State University, Columbus, OH, 43210, USA., J Boyden W; Charles Perkins Centre, Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., Bollman B; Department of Neurology, Washington University in St. Louis, St. Louis, MO, 63110, USA., Rogerson-Wood L; Charles Perkins Centre, Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia., S Davies D; Department of Neuropathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia., J Affleck A; Department of Neuropathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia., E Buckland M; Department of Neuropathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia., Harari O; Division of Neurogenetics, Neurobiology of Aging and Resilience Centre, Ohio State University, Columbus, OH, 43210, USA., Piccio L; Charles Perkins Centre, Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia. Laura.piccio@sydney.edu.au.; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia. Laura.piccio@sydney.edu.au., S Goldsbury C; Charles Perkins Centre, Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia. claire.goldsbury@sydney.edu.au.; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia. claire.goldsbury@sydney.edu.au.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Feb 16; Vol. 14 (1). Date of Electronic Publication: 2026 Feb 16.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
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  Data: Spatial characterisation of TREM2 expression in actively demyelinating multiple sclerosis lesions supports its key roles in lipid metabolic pathways.
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  Data: <searchLink fieldCode="AU" term="%22A+Aguirre+Candia+Y%22">A Aguirre Candia Y</searchLink>; Charles Perkins Centre, Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Aladyeva+E%22">Aladyeva E</searchLink>; Division of Neurogenetics, Neurobiology of Aging and Resilience Centre, Ohio State University, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22J+Boyden+W%22">J Boyden W</searchLink>; Charles Perkins Centre, Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Bollman+B%22">Bollman B</searchLink>; Department of Neurology, Washington University in St. Louis, St. Louis, MO, 63110, USA.<br /><searchLink fieldCode="AU" term="%22Rogerson-Wood+L%22">Rogerson-Wood L</searchLink>; Charles Perkins Centre, Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22S+Davies+D%22">S Davies D</searchLink>; Department of Neuropathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22J+Affleck+A%22">J Affleck A</searchLink>; Department of Neuropathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22E+Buckland+M%22">E Buckland M</searchLink>; Department of Neuropathology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Harari+O%22">Harari O</searchLink>; Division of Neurogenetics, Neurobiology of Aging and Resilience Centre, Ohio State University, Columbus, OH, 43210, USA.<br /><searchLink fieldCode="AU" term="%22Piccio+L%22">Piccio L</searchLink>; Charles Perkins Centre, Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia. Laura.piccio@sydney.edu.au.; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia. Laura.piccio@sydney.edu.au.<br /><searchLink fieldCode="AU" term="%22S+Goldsbury+C%22">S Goldsbury C</searchLink>; Charles Perkins Centre, Neuroscience, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia. claire.goldsbury@sydney.edu.au.; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia. claire.goldsbury@sydney.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101610673%22">Acta neuropathologica communications</searchLink> [Acta Neuropathol Commun] 2026 Feb 16; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 Feb 16.
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