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Potassium Bisulfite's Role in Developing a Robust Platform for Enantioenriched N-Alkylpyridinium Salts as Piperidine Precursors.

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Title: Potassium Bisulfite's Role in Developing a Robust Platform for Enantioenriched N-Alkylpyridinium Salts as Piperidine Precursors.
Authors: Selingo JD; Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States., King JR; Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States., Pio B; Department of Discovery Chemistry, Merck & Co. Inc., Rahway, New Jersey 07065, United States., Neel AJ; Department of Process Research and Development, Merck & Co. Inc., Boston, Massachusetts 02115, United States., Lam YH; Computational and Structural Chemistry, Merck & Co. Inc., Rahway, New Jersey 07065, United States., Paton RS; Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States., Maddess ML; Department of Discovery Chemistry, Merck & Co. Inc., Boston, Massachusetts 02115, United States., McNally A; Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
Source: Journal of the American Chemical Society [J Am Chem Soc] 2026 Mar 04; Vol. 148 (8), pp. 8621-8633. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE; PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Potassium Bisulfite's Role in Developing a Robust Platform for Enantioenriched N-Alkylpyridinium Salts as Piperidine Precursors.
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  Data: <searchLink fieldCode="AU" term="%22Selingo+JD%22">Selingo JD</searchLink>; Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.<br /><searchLink fieldCode="AU" term="%22King+JR%22">King JR</searchLink>; Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.<br /><searchLink fieldCode="AU" term="%22Pio+B%22">Pio B</searchLink>; Department of Discovery Chemistry, Merck & Co. Inc., Rahway, New Jersey 07065, United States.<br /><searchLink fieldCode="AU" term="%22Neel+AJ%22">Neel AJ</searchLink>; Department of Process Research and Development, Merck & Co. Inc., Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22Lam+YH%22">Lam YH</searchLink>; Computational and Structural Chemistry, Merck & Co. Inc., Rahway, New Jersey 07065, United States.<br /><searchLink fieldCode="AU" term="%22Paton+RS%22">Paton RS</searchLink>; Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.<br /><searchLink fieldCode="AU" term="%22Maddess+ML%22">Maddess ML</searchLink>; Department of Discovery Chemistry, Merck & Co. Inc., Boston, Massachusetts 02115, United States.<br /><searchLink fieldCode="AU" term="%22McNally+A%22">McNally A</searchLink>; Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
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  Data: <searchLink fieldCode="JN" term="%227503056%22">Journal of the American Chemical Society</searchLink> [J Am Chem Soc] 2026 Mar 04; Vol. 148 (8), pp. 8621-8633. <i>Date of Electronic Publication: </i>2026 Feb 17.
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        Value: 10.1021/jacs.5c20464
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              Text: 2026 Mar 04
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