Structure-to-Therapeutic Transformation of Nanohydrogels Triggers Calcium Overload for Potentiated Boron Neutron Capture Therapy.

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Title: Structure-to-Therapeutic Transformation of Nanohydrogels Triggers Calcium Overload for Potentiated Boron Neutron Capture Therapy.
Authors: Yang J; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.; Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China., Yang M; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Wang Z; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China., Luo X; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China., Peng B; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China., Yan R; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Lv L; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China., Wan J; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Chen K; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China., Chang YN; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China., Yuan H; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China., Liang T; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.; Spallation Neutron Source Science Center, Dongguan 523803, China., Gao L; Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China., Ma C; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China., Xing G; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China., Li J; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
Source: ACS nano [ACS Nano] 2026 Mar 03; Vol. 20 (8), pp. 7321-7332. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101313589 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-086X (Electronic) Linking ISSN: 19360851 NLM ISO Abbreviation: ACS Nano Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structure-to-Therapeutic Transformation of Nanohydrogels Triggers Calcium Overload for Potentiated Boron Neutron Capture Therapy.
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  Data: <searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.; Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China.<br /><searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Luo+X%22">Luo X</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Peng+B%22">Peng B</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Yan+R%22">Yan R</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Lv+L%22">Lv L</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Wan+J%22">Wan J</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.; University of Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Chang+YN%22">Chang YN</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Yuan+H%22">Yuan H</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Liang+T%22">Liang T</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.; Spallation Neutron Source Science Center, Dongguan 523803, China.<br /><searchLink fieldCode="AU" term="%22Gao+L%22">Gao L</searchLink>; Department of Chemistry, College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China.<br /><searchLink fieldCode="AU" term="%22Ma+C%22">Ma C</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Xing+G%22">Xing G</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Laboratory for Biomedical Effects of Nanomaterial and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.
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        Value: 10.1021/acsnano.5c22264
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