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Design, Synthesis, and Antitumor Evaluation of Benzamide Derivatives Targeting HOXA1 Function.

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Title: Design, Synthesis, and Antitumor Evaluation of Benzamide Derivatives Targeting HOXA1 Function.
Authors: Wang YJ; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China., Yang XN; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China., Wang F; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China., Wu XF; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China., Shi YJ; School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China., Yang Y; Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China., Peng XJ; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China., Yi H; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China., Li K; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China., Yuan J; Cancer Research Center, Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200331, China., Li ZR; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China., Gong F; School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China., Xue ST; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Feb 26; Vol. 69 (4), pp. 4090-4111. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
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  Data: Design, Synthesis, and Antitumor Evaluation of Benzamide Derivatives Targeting HOXA1 Function.
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  Data: <searchLink fieldCode="AU" term="%22Wang+YJ%22">Wang YJ</searchLink>; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.<br /><searchLink fieldCode="AU" term="%22Yang+XN%22">Yang XN</searchLink>; Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.<br /><searchLink fieldCode="AU" term="%22Wang+F%22">Wang F</searchLink>; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.<br /><searchLink fieldCode="AU" term="%22Wu+XF%22">Wu XF</searchLink>; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.<br /><searchLink fieldCode="AU" term="%22Shi+YJ%22">Shi YJ</searchLink>; School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.<br /><searchLink fieldCode="AU" term="%22Peng+XJ%22">Peng XJ</searchLink>; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.<br /><searchLink fieldCode="AU" term="%22Yi+H%22">Yi H</searchLink>; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.<br /><searchLink fieldCode="AU" term="%22Li+K%22">Li K</searchLink>; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.<br /><searchLink fieldCode="AU" term="%22Yuan+J%22">Yuan J</searchLink>; Cancer Research Center, Department of Biochemistry and Molecular Biology, Tongji University School of Medicine, Shanghai 200331, China.<br /><searchLink fieldCode="AU" term="%22Li+ZR%22">Li ZR</searchLink>; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.<br /><searchLink fieldCode="AU" term="%22Gong+F%22">Gong F</searchLink>; School of Pharmacy, Wenzhou Medical University, Wenzhou 325035, China.<br /><searchLink fieldCode="AU" term="%22Xue+ST%22">Xue ST</searchLink>; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Feb 26; Vol. 69 (4), pp. 4090-4111. <i>Date of Electronic Publication: </i>2026 Feb 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE; In Process
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        Value: 10.1021/acs.jmedchem.5c02745
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