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High efficiency CRISPR knock-in demonstrates that TCF1 is insufficient to reverse T cell exhaustion.

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Title: High efficiency CRISPR knock-in demonstrates that TCF1 is insufficient to reverse T cell exhaustion.
Authors: de Menezes MN; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia. maria.nogueirademenezes@petermac.org.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia. maria.nogueirademenezes@petermac.org., Chen AXY; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia., Kulkarni N; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia., Sampurno S; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia., Saw NYL; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia., Yap KM; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia., Pérez-Núñez I; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia., Roth S; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia., Deguit CDT; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia., Haugen B; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia., Ramsbottom KM; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia., Munoz I; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia., Beavis PA; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia., Parish IA; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia. ian.parish@petermac.org.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia. ian.parish@petermac.org.
Source: Nature communications [Nat Commun] 2026 Feb 17; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: High efficiency CRISPR knock-in demonstrates that TCF1 is insufficient to reverse T cell exhaustion.
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  Data: <searchLink fieldCode="AU" term="%22de+Menezes+MN%22">de Menezes MN</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia. maria.nogueirademenezes@petermac.org.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia. maria.nogueirademenezes@petermac.org.<br /><searchLink fieldCode="AU" term="%22Chen+AXY%22">Chen AXY</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Kulkarni+N%22">Kulkarni N</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Sampurno+S%22">Sampurno S</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Saw+NYL%22">Saw NYL</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Yap+KM%22">Yap KM</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Pérez-Núñez+I%22">Pérez-Núñez I</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Roth+S%22">Roth S</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Deguit+CDT%22">Deguit CDT</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Haugen+B%22">Haugen B</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Ramsbottom+KM%22">Ramsbottom KM</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Munoz+I%22">Munoz I</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Beavis+PA%22">Beavis PA</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia.<br /><searchLink fieldCode="AU" term="%22Parish+IA%22">Parish IA</searchLink>; Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, 3000, Victoria, Australia. ian.parish@petermac.org.; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, 3010, Australia. ian.parish@petermac.org.
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