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The evolution to hepta-refractory myeloma involves sequential loss of CD38, BCMA and GPRC5D.

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Title: The evolution to hepta-refractory myeloma involves sequential loss of CD38, BCMA and GPRC5D.
Authors: Riedhammer C; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany., Truger M; MLL Munich Leukemia Laboratory, Munich, Germany., Lee H; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada., Leypoldt LB; Department of Hematology, Oncology and Bone Marrow Transplantation With Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Early Career Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Meggendorfer M; MLL Munich Leukemia Laboratory, Munich, Germany., Hutter S; MLL Munich Leukemia Laboratory, Munich, Germany., Müller H; MLL Munich Leukemia Laboratory, Munich, Germany., Mersi J; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany., Kadel SK; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany., Buchwald T; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany., Kosch R; Department of Hematology, Oncology and Bone Marrow Transplantation With Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Helal M; Mildred Scheel Early Career Center, University Hospital Würzburg, Würzburg, Germany., Afrin N; Mildred Scheel Early Career Center, University Hospital Würzburg, Würzburg, Germany., Rosenwald A; Institute of Pathology, University of Würzburg, Würzburg, Germany., Gerhard-Hartmann E; Institute of Pathology, University of Würzburg, Würzburg, Germany., Brioli A; Department of Internal Medicine C, University Hospital of Greifswald, Greifswald, Germany.; Hannover Medical School, Clinic for Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover, Germany., Krönke J; Department of Internal Medicine C, University Hospital of Greifswald, Greifswald, Germany., Haferlach T; MLL Munich Leukemia Laboratory, Munich, Germany., Haferlach C; MLL Munich Leukemia Laboratory, Munich, Germany., Weisel KC; Department of Hematology, Oncology and Bone Marrow Transplantation With Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Neri P; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada., Einsele H; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany., Kortüm KM; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany., Waldschmidt JM; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany., Bahlis N; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada., Weinhold N; Heidelberg Myeloma Center, Department of Medicine V, University Hospital Heidelberg, Medical Faculty, Heidelberg University, Heidelberg, Germany.; Clinical Cooperation Unit Molecular Hematology/Oncology, Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., Rasche L; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany. Rasche_L@ukw.de.; Mildred Scheel Early Career Center, University Hospital Würzburg, Würzburg, Germany. Rasche_L@ukw.de.
Source: Leukemia [Leukemia] 2026 Apr; Vol. 40 (4), pp. 730-738. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
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  Data: The evolution to hepta-refractory myeloma involves sequential loss of CD38, BCMA and GPRC5D.
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  Data: <searchLink fieldCode="AU" term="%22Riedhammer+C%22">Riedhammer C</searchLink>; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Truger+M%22">Truger M</searchLink>; MLL Munich Leukemia Laboratory, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lee+H%22">Lee H</searchLink>; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Leypoldt+LB%22">Leypoldt LB</searchLink>; Department of Hematology, Oncology and Bone Marrow Transplantation With Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Early Career Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Meggendorfer+M%22">Meggendorfer M</searchLink>; MLL Munich Leukemia Laboratory, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Hutter+S%22">Hutter S</searchLink>; MLL Munich Leukemia Laboratory, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Müller+H%22">Müller H</searchLink>; MLL Munich Leukemia Laboratory, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Mersi+J%22">Mersi J</searchLink>; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kadel+SK%22">Kadel SK</searchLink>; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Buchwald+T%22">Buchwald T</searchLink>; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kosch+R%22">Kosch R</searchLink>; Department of Hematology, Oncology and Bone Marrow Transplantation With Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Helal+M%22">Helal M</searchLink>; Mildred Scheel Early Career Center, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Afrin+N%22">Afrin N</searchLink>; Mildred Scheel Early Career Center, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rosenwald+A%22">Rosenwald A</searchLink>; Institute of Pathology, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gerhard-Hartmann+E%22">Gerhard-Hartmann E</searchLink>; Institute of Pathology, University of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Brioli+A%22">Brioli A</searchLink>; Department of Internal Medicine C, University Hospital of Greifswald, Greifswald, Germany.; Hannover Medical School, Clinic for Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Krönke+J%22">Krönke J</searchLink>; Department of Internal Medicine C, University Hospital of Greifswald, Greifswald, Germany.<br /><searchLink fieldCode="AU" term="%22Haferlach+T%22">Haferlach T</searchLink>; MLL Munich Leukemia Laboratory, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Haferlach+C%22">Haferlach C</searchLink>; MLL Munich Leukemia Laboratory, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Weisel+KC%22">Weisel KC</searchLink>; Department of Hematology, Oncology and Bone Marrow Transplantation With Section of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Neri+P%22">Neri P</searchLink>; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Einsele+H%22">Einsele H</searchLink>; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kortüm+KM%22">Kortüm KM</searchLink>; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Waldschmidt+JM%22">Waldschmidt JM</searchLink>; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bahlis+N%22">Bahlis N</searchLink>; Arnie Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada.<br /><searchLink fieldCode="AU" term="%22Weinhold+N%22">Weinhold N</searchLink>; Heidelberg Myeloma Center, Department of Medicine V, University Hospital Heidelberg, Medical Faculty, Heidelberg University, Heidelberg, Germany.; Clinical Cooperation Unit Molecular Hematology/Oncology, Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rasche+L%22">Rasche L</searchLink>; Department of Internal Medicine 2, University Hospital of Würzburg, Würzburg, Germany. Rasche_L@ukw.de.; Mildred Scheel Early Career Center, University Hospital Würzburg, Würzburg, Germany. Rasche_L@ukw.de.
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  Data: <searchLink fieldCode="JN" term="%228704895%22">Leukemia</searchLink> [Leukemia] 2026 Apr; Vol. 40 (4), pp. 730-738. <i>Date of Electronic Publication: </i>2026 Feb 17.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%2C+Specialist+Journals%22">Nature Publishing Group, Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>8704895 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5551 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208876924%22">08876924 </searchLink><i>NLM ISO Abbreviation: </i>Leukemia <i>Subsets: </i>MEDLINE
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