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Structures of proteinase 3 and the CD177 receptor complex reveal a major autoantibody epitope.

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Title: Structures of proteinase 3 and the CD177 receptor complex reveal a major autoantibody epitope.
Authors: Zheng-Gérard C; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Joha J; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Carrasquero M; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., El Omari K; Diamond Light Source Limited, Harwell Science and Innovation Campus, Didcot, UK., Lowe E; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Dubey S; Department of Rheumatology, Oxford University Hospitals NHS FT, Oxford, OX3 7LD, UK.; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7HE, UK., Draper SJ; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Chang YC; Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan., Lin HH; Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan. hhlin@mail.cgu.edu.tw.; Department of Anatomic Pathology, Chang Gung Memorial Hospital at Linkou, Taoyuan, 333, Taiwan. hhlin@mail.cgu.edu.tw., Salama AD; UCL Centre for Kidney and Bladder Health, Royal Free Hospital, London, UK. a.salama@ucl.ac.uk., McHugh K; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. kirsty.mchugh@paediatrics.ox.ac.uk.; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. kirsty.mchugh@paediatrics.ox.ac.uk., Seiradake E; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. elena.seiradake@bioch.ox.ac.uk.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. elena.seiradake@bioch.ox.ac.uk.
Source: EMBO reports [EMBO Rep] 2026 Mar; Vol. 27 (6), pp. 1580-1606. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structures of proteinase 3 and the CD177 receptor complex reveal a major autoantibody epitope.
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  Data: <searchLink fieldCode="AU" term="%22Zheng-Gérard+C%22">Zheng-Gérard C</searchLink>; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.<br /><searchLink fieldCode="AU" term="%22Joha+J%22">Joha J</searchLink>; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.<br /><searchLink fieldCode="AU" term="%22Carrasquero+M%22">Carrasquero M</searchLink>; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.<br /><searchLink fieldCode="AU" term="%22El+Omari+K%22">El Omari K</searchLink>; Diamond Light Source Limited, Harwell Science and Innovation Campus, Didcot, UK.<br /><searchLink fieldCode="AU" term="%22Lowe+E%22">Lowe E</searchLink>; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.<br /><searchLink fieldCode="AU" term="%22Dubey+S%22">Dubey S</searchLink>; Department of Rheumatology, Oxford University Hospitals NHS FT, Oxford, OX3 7LD, UK.; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7HE, UK.<br /><searchLink fieldCode="AU" term="%22Draper+SJ%22">Draper SJ</searchLink>; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.<br /><searchLink fieldCode="AU" term="%22Chang+YC%22">Chang YC</searchLink>; Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+HH%22">Lin HH</searchLink>; Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, 333, Taiwan. hhlin@mail.cgu.edu.tw.; Department of Anatomic Pathology, Chang Gung Memorial Hospital at Linkou, Taoyuan, 333, Taiwan. hhlin@mail.cgu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Salama+AD%22">Salama AD</searchLink>; UCL Centre for Kidney and Bladder Health, Royal Free Hospital, London, UK. a.salama@ucl.ac.uk.<br /><searchLink fieldCode="AU" term="%22McHugh+K%22">McHugh K</searchLink>; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. kirsty.mchugh@paediatrics.ox.ac.uk.; Department of Paediatrics, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. kirsty.mchugh@paediatrics.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Seiradake+E%22">Seiradake E</searchLink>; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. elena.seiradake@bioch.ox.ac.uk.; Kavli Institute for Nanoscience Discovery, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. elena.seiradake@bioch.ox.ac.uk.
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