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Caldesmon-1-mediated actin dynamics is essential for osteogenic differentiation of aortic valve interstitial cells.

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Title: Caldesmon-1-mediated actin dynamics is essential for osteogenic differentiation of aortic valve interstitial cells.
Authors: Komoda M; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan., Sakaue T; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan. sakaue@m.ehime-u.ac.jp.; Department of Cell Growth and Tumor Regulation, Proteo-Science Center (PROS), PIAS, Toon, Ehime, Japan. sakaue@m.ehime-u.ac.jp., Nakao Y; Department of Cardiology, Pulmonology, Hypertension, and Nephrology, Ehime University Graduate School of Medicine, Ehime, Japan., Sakamoto H; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan., Fukunishi T; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan., Higaki T; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan., Aono J; Department of Cardiology, Pulmonology, Hypertension, and Nephrology, Ehime University Graduate School of Medicine, Ehime, Japan., Kurobe H; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan., Kurata M; Department of Pathology, Division of Analytical Pathology, Proteo-Science Center (PROS), PIAS, Ehime University Graduate School of Medicine, Ehime, Japan., Nishimura T; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan., Izutani H; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan. izutani@m.ehime-u.ac.jp.
Source: Scientific reports [Sci Rep] 2026 Feb 17; Vol. 16 (1). Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Komoda+M%22">Komoda M</searchLink>; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Sakaue+T%22">Sakaue T</searchLink>; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan. sakaue@m.ehime-u.ac.jp.; Department of Cell Growth and Tumor Regulation, Proteo-Science Center (PROS), PIAS, Toon, Ehime, Japan. sakaue@m.ehime-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Nakao+Y%22">Nakao Y</searchLink>; Department of Cardiology, Pulmonology, Hypertension, and Nephrology, Ehime University Graduate School of Medicine, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Sakamoto+H%22">Sakamoto H</searchLink>; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Fukunishi+T%22">Fukunishi T</searchLink>; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Higaki+T%22">Higaki T</searchLink>; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Aono+J%22">Aono J</searchLink>; Department of Cardiology, Pulmonology, Hypertension, and Nephrology, Ehime University Graduate School of Medicine, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Kurobe+H%22">Kurobe H</searchLink>; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Kurata+M%22">Kurata M</searchLink>; Department of Pathology, Division of Analytical Pathology, Proteo-Science Center (PROS), PIAS, Ehime University Graduate School of Medicine, Ehime, Japan.<br /><searchLink fieldCode="AU" term="%22Nishimura+T%22">Nishimura T</searchLink>; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan.<br /><searchLink fieldCode="AU" term="%22Izutani+H%22">Izutani H</searchLink>; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon-City, Ehime, 791-0295, Japan. izutani@m.ehime-u.ac.jp.
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  Data: <searchLink fieldCode="JN" term="%22101563288%22">Scientific reports</searchLink> [Sci Rep] 2026 Feb 17; Vol. 16 (1). <i>Date of Electronic Publication: </i>2026 Feb 17.
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              Text: 2026 Feb 17
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