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Oxaliplatin-induced neuropathy after total neoadjuvant therapy for rectal cancer: Dose-response relationship and impact on quality of life.

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Title: Oxaliplatin-induced neuropathy after total neoadjuvant therapy for rectal cancer: Dose-response relationship and impact on quality of life.
Authors: Wurschi GW; Department of Radiotherapy and Radiation Oncology, Jena University Hospital, Jena, Germany.; Comprehensive Cancer Center Central Germany (CCCG), Partner Site Jena, Jena, Germany., Hinz A; Department of Medical Psychology and Medical Sociology, University Medical Center Leipzig, Leipzig, Germany.; Comprehensive Cancer Center Central Germany (CCCG), Partner Site Leipzig, Leipzig, Germany., Schneider M; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Becker JN; Department of Radiotherapy, Hannover Medical School, Hannover, Germany., Frerker B; Department of Radiotherapy and Radiation Oncology, Rostock University Medical Center, Rostock, Germany., Vorbach SM; Department of Radiation Oncology, Medical University of Innsbruck, Innsbruck, Austria., Ehret F; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Radiation Oncology, Berlin, Germany.; German Cancer Consortium (DKTK), Partner Site Berlin, a partnership between DKFZ and Charité - Universitätsmedizin Berlin, Berlin, Germany., Diefenhardt M; Department of Radiotherapy and Oncology, University Hospital, Goethe University Frankfurt, Frankfurt am Main, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany., Schunn F; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany., von Gruben ME; Department of Radiotherapy and Radiation Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany., Büttner M; Department of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK), Partner Site Tübingen, Tübingen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Hoffmann E; Department of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK), Partner Site Tübingen, Tübingen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Rühle A; Comprehensive Cancer Center Central Germany (CCCG), Partner Site Leipzig, Leipzig, Germany.; Department of Radiation Oncology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK), Partner Site DKTK-Freiburg, Freiburg im Breisgau, Germany.; Department of Radiation Oncology, University Medical Center Leipzig, Leipzig, Germany., Beier J; Comprehensive Cancer Center Central Germany (CCCG), Partner Site Leipzig, Leipzig, Germany.; Department of Radiation Oncology, University Medical Center Leipzig, Leipzig, Germany., Ferdinandus S; Department of Radiation Oncology, Cyberknife and Radiotherapy, Faculty of Medicine and University Hospital Cologne, Köln, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Köln, Germany., Trommer M; Department of Radiation Oncology, Cyberknife and Radiotherapy, Faculty of Medicine and University Hospital Cologne, Köln, Germany.; Department I of Internal Medicine, Center of Integrated Oncology Aachen Bonn Cologne Düsseldorf, University Hospital of Cologne, Cologne, Germany., Sahin EC; Department of Radiotherapy, West German Cancer Center, University Hospital Essen, Essen, Germany., Hlouschek J; Department of Radiotherapy, West German Cancer Center, University Hospital Essen, Essen, Germany., Aninditha K; Department of Radiooncology, Klinikum Stuttgart, Stuttgart, Germany., von Ohlen DS; Department of Radiotherapy, University Medical Center Schleswig-Holstein/Lübeck, Lübeck, Germany., Kaufmann J; Department of Radiooncology, University Medical Center of the Johannes-Gutenberg-University Mainz, Mainz, Germany., Depardon A; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Ha HM; Department of Radiation Oncology, Otto von Guericke Universität Magdeburg, Magdeburg, Germany., Kessler C; Department of Radiation Oncology, Technical University of Munich (TUM), School of Medicine and Klinikum Rechts der Isar, München, Germany., Cieslak A; Department of Radiation Oncology, University Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Radiotherapy and Radiation Oncology, Bremen, Germany., Trommer S; Department for Radiotherapy, University Hospital Halle, Halle (Saale), Germany., Fabian A; Department of Radiation Oncology, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany., Rißner F; Center for Clinical Studies, Jena University Hospital, Jena, Germany., Römer M; Department of Radiotherapy and Radiation Oncology, Jena University Hospital, Jena, Germany.; Comprehensive Cancer Center Central Germany (CCCG), Partner Site Jena, Jena, Germany., Pietschmann K; Department of Radiotherapy and Radiation Oncology, Jena University Hospital, Jena, Germany.; Comprehensive Cancer Center Central Germany (CCCG), Partner Site Jena, Jena, Germany.
Source: International journal of cancer [Int J Cancer] 2026 Jul 01; Vol. 159 (1), pp. 198-209. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE
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  Data: Oxaliplatin-induced neuropathy after total neoadjuvant therapy for rectal cancer: Dose-response relationship and impact on quality of life.
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  Data: <searchLink fieldCode="AU" term="%22Wurschi+GW%22">Wurschi GW</searchLink>; Department of Radiotherapy and Radiation Oncology, Jena University Hospital, Jena, Germany.; Comprehensive Cancer Center Central Germany (CCCG), Partner Site Jena, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Hinz+A%22">Hinz A</searchLink>; Department of Medical Psychology and Medical Sociology, University Medical Center Leipzig, Leipzig, Germany.; Comprehensive Cancer Center Central Germany (CCCG), Partner Site Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+M%22">Schneider M</searchLink>; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Becker+JN%22">Becker JN</searchLink>; Department of Radiotherapy, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Frerker+B%22">Frerker B</searchLink>; Department of Radiotherapy and Radiation Oncology, Rostock University Medical Center, Rostock, Germany.<br /><searchLink fieldCode="AU" term="%22Vorbach+SM%22">Vorbach SM</searchLink>; Department of Radiation Oncology, Medical University of Innsbruck, Innsbruck, Austria.<br /><searchLink fieldCode="AU" term="%22Ehret+F%22">Ehret F</searchLink>; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Radiation Oncology, Berlin, Germany.; German Cancer Consortium (DKTK), Partner Site Berlin, a partnership between DKFZ and Charité - Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Diefenhardt+M%22">Diefenhardt M</searchLink>; Department of Radiotherapy and Oncology, University Hospital, Goethe University Frankfurt, Frankfurt am Main, Germany.; Frankfurt Cancer Institute (FCI), Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Schunn+F%22">Schunn F</searchLink>; Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22von+Gruben+ME%22">von Gruben ME</searchLink>; Department of Radiotherapy and Radiation Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Büttner+M%22">Büttner M</searchLink>; Department of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK), Partner Site Tübingen, Tübingen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hoffmann+E%22">Hoffmann E</searchLink>; Department of Radiation Oncology, University Hospital Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK), Partner Site Tübingen, Tübingen, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rühle+A%22">Rühle A</searchLink>; Comprehensive Cancer Center Central Germany (CCCG), Partner Site Leipzig, Leipzig, Germany.; Department of Radiation Oncology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK), Partner Site DKTK-Freiburg, Freiburg im Breisgau, Germany.; Department of Radiation Oncology, University Medical Center Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Beier+J%22">Beier J</searchLink>; Comprehensive Cancer Center Central Germany (CCCG), Partner Site Leipzig, Leipzig, Germany.; Department of Radiation Oncology, University Medical Center Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Ferdinandus+S%22">Ferdinandus S</searchLink>; Department of Radiation Oncology, Cyberknife and Radiotherapy, Faculty of Medicine and University Hospital Cologne, Köln, Germany.; Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), Köln, Germany.<br /><searchLink fieldCode="AU" term="%22Trommer+M%22">Trommer M</searchLink>; Department of Radiation Oncology, Cyberknife and Radiotherapy, Faculty of Medicine and University Hospital Cologne, Köln, Germany.; Department I of Internal Medicine, Center of Integrated Oncology Aachen Bonn Cologne Düsseldorf, University Hospital of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Sahin+EC%22">Sahin EC</searchLink>; Department of Radiotherapy, West German Cancer Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Hlouschek+J%22">Hlouschek J</searchLink>; Department of Radiotherapy, West German Cancer Center, University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Aninditha+K%22">Aninditha K</searchLink>; Department of Radiooncology, Klinikum Stuttgart, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22von+Ohlen+DS%22">von Ohlen DS</searchLink>; Department of Radiotherapy, University Medical Center Schleswig-Holstein/Lübeck, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Kaufmann+J%22">Kaufmann J</searchLink>; Department of Radiooncology, University Medical Center of the Johannes-Gutenberg-University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Depardon+A%22">Depardon A</searchLink>; Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Ha+HM%22">Ha HM</searchLink>; Department of Radiation Oncology, Otto von Guericke Universität Magdeburg, Magdeburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kessler+C%22">Kessler C</searchLink>; Department of Radiation Oncology, Technical University of Munich (TUM), School of Medicine and Klinikum Rechts der Isar, München, Germany.<br /><searchLink fieldCode="AU" term="%22Cieslak+A%22">Cieslak A</searchLink>; Department of Radiation Oncology, University Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Center for Radiotherapy and Radiation Oncology, Bremen, Germany.<br /><searchLink fieldCode="AU" term="%22Trommer+S%22">Trommer S</searchLink>; Department for Radiotherapy, University Hospital Halle, Halle (Saale), Germany.<br /><searchLink fieldCode="AU" term="%22Fabian+A%22">Fabian A</searchLink>; Department of Radiation Oncology, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Rißner+F%22">Rißner F</searchLink>; Center for Clinical Studies, Jena University Hospital, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Römer+M%22">Römer M</searchLink>; Department of Radiotherapy and Radiation Oncology, Jena University Hospital, Jena, Germany.; Comprehensive Cancer Center Central Germany (CCCG), Partner Site Jena, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Pietschmann+K%22">Pietschmann K</searchLink>; Department of Radiotherapy and Radiation Oncology, Jena University Hospital, Jena, Germany.; Comprehensive Cancer Center Central Germany (CCCG), Partner Site Jena, Jena, Germany.
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