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Defining a serum cortisol cutoff level post-CRH stimulation for diagnosing ACTH deficiency: A retrospective study validated by a nationwide registry.

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Title: Defining a serum cortisol cutoff level post-CRH stimulation for diagnosing ACTH deficiency: A retrospective study validated by a nationwide registry.
Authors: Izuchi T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan., Iwama S; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan., Yamagami A; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan., Kobayashi T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan., Suzuki K; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan., Murase T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan., Ando M; Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan., Murasawa S; Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Mukai K; Department of Metabolic Medicine, the University of Osaka Graduate School of Medicine, Osaka, Japan., Takagi H; Department of Endocrinology and Diabetology, Nagoya City University East Medical Center, Nagoya, Japan., Fukuoka H; Division of Diabetes and Endocrinology, Kobe University Hospital, Kobe, Japan., Handa T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Clinical Research Education, Nagoya University Graduate School of Medicine, Nagoya, Japan., Onoue T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan., Miyata T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan., Sugiyama M; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan., Hagiwara D; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan., Suga H; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan., Banno R; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan., Tahara S; Department of Neurological Surgery, Nippon Medical School Musashikosugi Hospital, Kawasaki, Japan., Nishiyama M; Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi, Japan., Kageyama K; Division of Diabetes, Metabolism, and Endocrinology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan., Otsuki M; Department of Endocrinology, Tokyo Women's Medical University, Tokyo, Japan., Arima H; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Source: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2026 Feb 02; Vol. 17, pp. 1741709. Date of Electronic Publication: 2026 Feb 02 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Izuchi+T%22">Izuchi T</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Iwama+S%22">Iwama S</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Yamagami+A%22">Yamagami A</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Kobayashi+T%22">Kobayashi T</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+K%22">Suzuki K</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Murase+T%22">Murase T</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Ando+M%22">Ando M</searchLink>; Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Murasawa+S%22">Murasawa S</searchLink>; Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.<br /><searchLink fieldCode="AU" term="%22Mukai+K%22">Mukai K</searchLink>; Department of Metabolic Medicine, the University of Osaka Graduate School of Medicine, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Takagi+H%22">Takagi H</searchLink>; Department of Endocrinology and Diabetology, Nagoya City University East Medical Center, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Fukuoka+H%22">Fukuoka H</searchLink>; Division of Diabetes and Endocrinology, Kobe University Hospital, Kobe, Japan.<br /><searchLink fieldCode="AU" term="%22Handa+T%22">Handa T</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Department of Clinical Research Education, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Onoue+T%22">Onoue T</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Miyata+T%22">Miyata T</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Sugiyama+M%22">Sugiyama M</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Hagiwara+D%22">Hagiwara D</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Suga+H%22">Suga H</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Banno+R%22">Banno R</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.; Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan.<br /><searchLink fieldCode="AU" term="%22Tahara+S%22">Tahara S</searchLink>; Department of Neurological Surgery, Nippon Medical School Musashikosugi Hospital, Kawasaki, Japan.<br /><searchLink fieldCode="AU" term="%22Nishiyama+M%22">Nishiyama M</searchLink>; Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi, Japan.<br /><searchLink fieldCode="AU" term="%22Kageyama+K%22">Kageyama K</searchLink>; Division of Diabetes, Metabolism, and Endocrinology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.<br /><searchLink fieldCode="AU" term="%22Otsuki+M%22">Otsuki M</searchLink>; Department of Endocrinology, Tokyo Women's Medical University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Arima+H%22">Arima H</searchLink>; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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