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Immunoglobulin NGS enhance residual disease detection and prognosis in pediatric Ph+ acute lymphoblastic leukemia.

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Title: Immunoglobulin NGS enhance residual disease detection and prognosis in pediatric Ph+ acute lymphoblastic leukemia.
Authors: Chang L; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Chang J; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Zhao B; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Gu Y; NeoImmune Co., Ltd., Shenzhen, China., Zou Y; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Chen Y; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Guo Y; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Chen X; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Yang W; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Duan Y; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Hu T; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Liu X; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Ruan M; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Lu Z; NeoImmune Co., Ltd., Shenzhen, China., Lu S; NeoImmune Co., Ltd., Shenzhen, China., Wang X; NeoImmune Co., Ltd., Shenzhen, China., Dong L; NeoImmune Co., Ltd., Shenzhen, China., Wu J; NeoImmune Co., Ltd., Shenzhen, China., Jia Y; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Liu X; Shenzhen International Graduate School, Tsinghua University, Shenzhen, China., Zhu X; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China., Zhang L; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.
Source: Frontiers in immunology [Front Immunol] 2026 Feb 02; Vol. 16, pp. 1677013. Date of Electronic Publication: 2026 Feb 02 (Print Publication: 2025).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Immunoglobulin NGS enhance residual disease detection and prognosis in pediatric Ph+ acute lymphoblastic leukemia.
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  Data: <searchLink fieldCode="AU" term="%22Chang+L%22">Chang L</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Chang+J%22">Chang J</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Zhao+B%22">Zhao B</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Gu+Y%22">Gu Y</searchLink>; NeoImmune Co., Ltd., Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Zou+Y%22">Zou Y</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Guo+Y%22">Guo Y</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Yang+W%22">Yang W</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Duan+Y%22">Duan Y</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Hu+T%22">Hu T</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Ruan+M%22">Ruan M</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Lu+Z%22">Lu Z</searchLink>; NeoImmune Co., Ltd., Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Lu+S%22">Lu S</searchLink>; NeoImmune Co., Ltd., Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; NeoImmune Co., Ltd., Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Dong+L%22">Dong L</searchLink>; NeoImmune Co., Ltd., Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; NeoImmune Co., Ltd., Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Jia+Y%22">Jia Y</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Zhu+X%22">Zhu X</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.; Tianjin Institutes of Health Science, Tianjin, China.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Feb 02; Vol. 16, pp. 1677013. <i>Date of Electronic Publication: </i>2026 Feb 02 (<i>Print Publication: </i>2025).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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