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Safety, immunogenicity, and optimal dosing of VLPCOV-02, a SARS-CoV-2 saRNA vaccine with modified 5-methylcytosine base.

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Title: Safety, immunogenicity, and optimal dosing of VLPCOV-02, a SARS-CoV-2 saRNA vaccine with modified 5-methylcytosine base.
Authors: Aboshi M; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan., Kawakami D; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan., Kono K; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan., Nishiyama A; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka 567-0085, Japan., Nogimori T; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka 567-0085, Japan., Sunada Y; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan., Matsuda K; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA., Sekida T; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan., Suga S; National Hospital Organization, Mie National Hospital, Tsu, Mie 514-0125, Japan., Smith JF; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA., Sato N; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan., Yamamoto T; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka 567-0085, Japan.; Laboratory of Aging and Immune Regulation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Osaka 565-0871, Japan.; Department of Virology and Immunology, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan., Akahata W; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan.
Source: IScience [iScience] 2026 Jan 21; Vol. 29 (2), pp. 114766. Date of Electronic Publication: 2026 Jan 21 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety, immunogenicity, and optimal dosing of VLPCOV-02, a SARS-CoV-2 saRNA vaccine with modified 5-methylcytosine base.
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  Data: <searchLink fieldCode="AU" term="%22Aboshi+M%22">Aboshi M</searchLink>; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan.<br /><searchLink fieldCode="AU" term="%22Kawakami+D%22">Kawakami D</searchLink>; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan.<br /><searchLink fieldCode="AU" term="%22Kono+K%22">Kono K</searchLink>; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan.<br /><searchLink fieldCode="AU" term="%22Nishiyama+A%22">Nishiyama A</searchLink>; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka 567-0085, Japan.<br /><searchLink fieldCode="AU" term="%22Nogimori+T%22">Nogimori T</searchLink>; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka 567-0085, Japan.<br /><searchLink fieldCode="AU" term="%22Sunada+Y%22">Sunada Y</searchLink>; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan.<br /><searchLink fieldCode="AU" term="%22Matsuda+K%22">Matsuda K</searchLink>; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Sekida+T%22">Sekida T</searchLink>; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan.<br /><searchLink fieldCode="AU" term="%22Suga+S%22">Suga S</searchLink>; National Hospital Organization, Mie National Hospital, Tsu, Mie 514-0125, Japan.<br /><searchLink fieldCode="AU" term="%22Smith+JF%22">Smith JF</searchLink>; VLP Therapeutics, Inc., Gaithersburg, MD 20878, USA.<br /><searchLink fieldCode="AU" term="%22Sato+N%22">Sato N</searchLink>; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan.<br /><searchLink fieldCode="AU" term="%22Yamamoto+T%22">Yamamoto T</searchLink>; Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka 567-0085, Japan.; Laboratory of Aging and Immune Regulation, Graduate School of Pharmaceutical Sciences, The University of Osaka, Osaka 565-0871, Japan.; Department of Virology and Immunology, Graduate School of Medicine, The University of Osaka, Osaka 565-0871, Japan.<br /><searchLink fieldCode="AU" term="%22Akahata+W%22">Akahata W</searchLink>; VLP Therapeutics Japan, Inc., 1-2-9 Nishi-Shinbashi, Minato-ku, Tokyo 105-0003, Japan.
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