Transarterial chemoembolization (TACE) combined with immunotherapy and anti-angiogenic agents in intermediate-stage hepatocellular carcinoma (CHANCE2202): a target trial emulation study.
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| Title: | Transarterial chemoembolization (TACE) combined with immunotherapy and anti-angiogenic agents in intermediate-stage hepatocellular carcinoma (CHANCE2202): a target trial emulation study. |
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| Authors: | Chen JJ; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.; National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University); Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China., Jin ZC; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.; National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University); Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China., Zhou JW; Department of Health Statistics, School of Public Health, Chongqing Medical University, Chongqing, China.; Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China., Ding R; Department of Minimally Invasive Interventional Medicine, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China., Tie J; National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, China., Xin YJ; Department of Minimally Invasive Comprehensive Treatment of Cancer, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China., Zhang L; Department of Hepatic Oncology, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China., Huang M; Department of Minimally Invasive Interventional Medicine, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China., Zhu XL; Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China., Zhou GH; Hepatobiliary and Pancreatic Interventional Treatment Center, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Ji F; Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education of China, Xi'an, China., Zhu KS; Department of Minimally Invasive Interventional Radiology and Radiology Center, and Minimally Invasive and Interventional Cancer Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Shi HB; Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China., Wu YM; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.; National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University); Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China., Zhang WH; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.; National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University); Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China., Yang WZ; Department of Interventional Radiology, Union Hospital of Fujian Medical University, Fuzhou, China., Ding WB; Department of Interventional Radiology, Nantong First People's Hospital, Nantong, China., Chen JZ; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China., Ji JS; Department of Radiology, Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, School of Medicine, Lishui Hospital of Zhejiang University, Lishui, China., Xu AB; Department of Interventional Therapy, Nantong Tumor Hospital, Nantong, China., Zhao W; Department of Radiology, First Affiliated Hospital of Kunming Medical University, Kunming, China., Wang Q; Department of Interventional Radiology, Third Affiliated Hospital of Soochow University, Changzhou First Hospital, Changzhou, China., Dai ZY; Department of Interventional Radiology, Yancheng Third People's Hospital, Yancheng, China., Zheng CS; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Zhao JW; Department of Interventional and Vascular Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China., Liu RB; Department of Interventional Radiology, The Tumor Hospital of Harbin Medical University, Harbin, China., Wu JB; Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, China., Cao GS; Department of Interventional Therapy, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China., Xing WG; Department of Interventional Oncology, Tianjin Medical University Cancer Hospital, Tianjin, China., Duan XH; Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Shao HB; Department of Interventional Radiology, The First Hospital of China Medical University, Shenyang, China., Zhong BY; Department of Interventional Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China., Zhao Y; Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China., Zhu HD; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.; National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University); Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China., Ren ZG; Department of Hepatic Oncology, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China., Teng GJ; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.; National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University); Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China. |
| Source: | EClinicalMedicine [EClinicalMedicine] 2026 Feb 06; Vol. 92, pp. 103766. Date of Electronic Publication: 2026 Feb 06 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: The Lancet Country of Publication: England NLM ID: 101733727 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5370 (Electronic) Linking ISSN: 25895370 NLM ISO Abbreviation: EClinicalMedicine Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41705016 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Transarterial chemoembolization (TACE) combined with immunotherapy and anti-angiogenic agents in intermediate-stage hepatocellular carcinoma (CHANCE2202): a target trial emulation study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Chen+JJ%22">Chen JJ</searchLink>; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.; National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University); Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Jin+ZC%22">Jin ZC</searchLink>; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.; National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University); Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhou+JW%22">Zhou JW</searchLink>; Department of Health Statistics, School of Public Health, Chongqing Medical University, Chongqing, China.; Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Ding+R%22">Ding R</searchLink>; Department of Minimally Invasive Interventional Medicine, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.<br /><searchLink fieldCode="AU" term="%22Tie+J%22">Tie J</searchLink>; National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Xin+YJ%22">Xin YJ</searchLink>; Department of Minimally Invasive Comprehensive Treatment of Cancer, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Department of Hepatic Oncology, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Huang+M%22">Huang M</searchLink>; Department of Minimally Invasive Interventional Medicine, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.<br /><searchLink fieldCode="AU" term="%22Zhu+XL%22">Zhu XL</searchLink>; Department of Interventional Radiology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhou+GH%22">Zhou GH</searchLink>; Hepatobiliary and Pancreatic Interventional Treatment Center, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ji+F%22">Ji F</searchLink>; Department of Infectious Diseases, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.; Key Laboratory of Environment and Genes Related to Diseases, Xi'an Jiaotong University, Ministry of Education of China, Xi'an, China.<br /><searchLink fieldCode="AU" term="%22Zhu+KS%22">Zhu KS</searchLink>; Department of Minimally Invasive Interventional Radiology and Radiology Center, and Minimally Invasive and Interventional Cancer Center, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Shi+HB%22">Shi HB</searchLink>; Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wu+YM%22">Wu YM</searchLink>; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.; National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University); Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+WH%22">Zhang WH</searchLink>; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.; National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University); Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Yang+WZ%22">Yang WZ</searchLink>; Department of Interventional Radiology, Union Hospital of Fujian Medical University, Fuzhou, China.<br /><searchLink fieldCode="AU" term="%22Ding+WB%22">Ding WB</searchLink>; Department of Interventional Radiology, Nantong First People's Hospital, Nantong, China.<br /><searchLink fieldCode="AU" term="%22Chen+JZ%22">Chen JZ</searchLink>; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Ji+JS%22">Ji JS</searchLink>; Department of Radiology, Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, School of Medicine, Lishui Hospital of Zhejiang University, Lishui, China.<br /><searchLink fieldCode="AU" term="%22Xu+AB%22">Xu AB</searchLink>; Department of Interventional Therapy, Nantong Tumor Hospital, Nantong, China.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; Department of Radiology, First Affiliated Hospital of Kunming Medical University, Kunming, China.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Department of Interventional Radiology, Third Affiliated Hospital of Soochow University, Changzhou First Hospital, Changzhou, China.<br /><searchLink fieldCode="AU" term="%22Dai+ZY%22">Dai ZY</searchLink>; Department of Interventional Radiology, Yancheng Third People's Hospital, Yancheng, China.<br /><searchLink fieldCode="AU" term="%22Zheng+CS%22">Zheng CS</searchLink>; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhao+JW%22">Zhao JW</searchLink>; Department of Interventional and Vascular Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+RB%22">Liu RB</searchLink>; Department of Interventional Radiology, The Tumor Hospital of Harbin Medical University, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Wu+JB%22">Wu JB</searchLink>; Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.<br /><searchLink fieldCode="AU" term="%22Cao+GS%22">Cao GS</searchLink>; Department of Interventional Therapy, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Xing+WG%22">Xing WG</searchLink>; Department of Interventional Oncology, Tianjin Medical University Cancer Hospital, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Duan+XH%22">Duan XH</searchLink>; Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.<br /><searchLink fieldCode="AU" term="%22Shao+HB%22">Shao HB</searchLink>; Department of Interventional Radiology, The First Hospital of China Medical University, Shenyang, China.<br /><searchLink fieldCode="AU" term="%22Zhong+BY%22">Zhong BY</searchLink>; Department of Interventional Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhao+Y%22">Zhao Y</searchLink>; Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Zhu+HD%22">Zhu HD</searchLink>; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.; National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University); Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Ren+ZG%22">Ren ZG</searchLink>; Department of Hepatic Oncology, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China.; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Teng+GJ%22">Teng GJ</searchLink>; Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.; National Innovation Platform for Integration of Medical Engineering Education (NMEE) (Southeast University); Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101733727%22">EClinicalMedicine</searchLink> [EClinicalMedicine] 2026 Feb 06; Vol. 92, pp. 103766. <i>Date of Electronic Publication: </i>2026 Feb 06 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22The+Lancet%22">The Lancet </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101733727 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>2589-5370 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225895370%22">25895370 </searchLink><i>NLM ISO Abbreviation: </i>EClinicalMedicine <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41705016 |
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