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LOX Inhibition Disrupts a Collagen-Integrin-MYC Axis to Suppress Progression of Invasive Lobular Carcinoma.

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Title: LOX Inhibition Disrupts a Collagen-Integrin-MYC Axis to Suppress Progression of Invasive Lobular Carcinoma.
Authors: Flaherty RL; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Hughes F; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Sflomos G; ISREC-Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Ronchi C; ISREC-Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Kemp H; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Roumeliotis TI; Functional Proteomics, The Institute of Cancer Research, London, United Kingdom., Nicholas AA; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Ambrosini G; Bioinformatics Competence Center, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Bioinformatics Competence Center, Université de Lausanne, Lausanne, Switzerland., Ziehme A; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Becker S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Yang WW; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Zhang Y; ISREC-Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Quinn HM; ISREC-Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Battista L; ISREC-Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland., Padda H; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Pezot S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Jouny S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Liu Y; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Brough R; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Marlow R; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Iravani M; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Okines AFC; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden Hospital, London, United Kingdom., Turner NC; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.; The Royal Marsden Hospital, London, United Kingdom., Stravodimou A; Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland., Zaman K; Lausanne University Hospital CHUV, University of Lausanne, Lausanne, Switzerland., Fiche M; International Cancer Prevention Institute (ICPI), Epalinges, Switzerland., Howard BA; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Choudhary JS; Functional Proteomics, The Institute of Cancer Research, London, United Kingdom., Sanz-Moreno V; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Isacke CM; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Perryman L; Pharmaxis, Frenchs Forest, Australia., Jarolimek W; Pharmaxis, Frenchs Forest, Australia., Haider S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Lord CJ; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom., Brisken C; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.; ISREC-Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Source: Cancer research [Cancer Res] 2026 May 15; Vol. 86 (10), pp. 2487-2507.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE
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  Data: LOX Inhibition Disrupts a Collagen-Integrin-MYC Axis to Suppress Progression of Invasive Lobular Carcinoma.
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Functional Proteomics, The Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Nicholas+AA%22">Nicholas AA</searchLink>; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Ambrosini+G%22">Ambrosini G</searchLink>; Bioinformatics Competence Center, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Bioinformatics Competence Center, Université de Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ziehme+A%22">Ziehme A</searchLink>; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Becker+S%22">Becker S</searchLink>; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Yang+WW%22">Yang WW</searchLink>; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; 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Functional Proteomics, The Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sanz-Moreno+V%22">Sanz-Moreno V</searchLink>; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Isacke+CM%22">Isacke CM</searchLink>; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Perryman+L%22">Perryman L</searchLink>; Pharmaxis, Frenchs Forest, Australia.<br /><searchLink fieldCode="AU" term="%22Jarolimek+W%22">Jarolimek W</searchLink>; Pharmaxis, Frenchs Forest, Australia.<br /><searchLink fieldCode="AU" term="%22Haider+S%22">Haider S</searchLink>; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lord+CJ%22">Lord CJ</searchLink>; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Brisken+C%22">Brisken C</searchLink>; 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