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Contribution of depressive symptom load on prediction of transition to bipolar disorders: Results from the prospective-longitudinal multi-method Early-BipoLife study.

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Title: Contribution of depressive symptom load on prediction of transition to bipolar disorders: Results from the prospective-longitudinal multi-method Early-BipoLife study.
Authors: Petersen T; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany., Martini J; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany., Bauer M; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany., Bechdolf A; Department of Psychiatry, Psychotherapy and Psychosomatics, Vivantes Hospital at Urban and Vivantes Hospital at Friedrichshain, Berlin, Germany; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charté Universitätsmedizin Berlin, Berlin, Germany; Brandenburg Theodor Fontane, Neuruppin, Germany., Bermpohl F; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charté Universitätsmedizin Berlin, Berlin, Germany; Brandenburg Theodor Fontane, Neuruppin, Germany., Berndt C; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany., Bröckel-Bundt KL; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany., Sperling T; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany., Correll CU; Department of Child- and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA., Dannlowski U; Institute for Translational Psychiatry, University of Münster, Münster, Germany., Falkenberg I; Department for Psychiatry and Psychotherapy, University Hospital Marburg, Marburg, Germany., Fallgatter AJ; Tübingen Center for Mental Health (TüCMH), Department of General Psychiatry and Psychotherapy, University Hospital Tübingen, Tübingen, Germany., Fusar-Poli P; EPIC Lab, Department of Psychosis Studies, King's College London, London, UK; Department of Brain and Behavioral Health Sciences, University of Pavia, Pavia, Italy., Jansen A; Department for Psychiatry and Psychotherapy, University Hospital Marburg, Marburg, Germany., Juckel G; Department for Psychiatry and Psychotherapy, University Hospital Marburg, Marburg, Germany., Kircher T; Department for Psychiatry and Psychotherapy, University Hospital Marburg, Marburg, Germany., Kittel-Schneider S; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Würzburg, Würzburg, Germany; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland., Krüger-Özgürdal S; Department of Psychiatry and Psychotherapy, LWL-University Hospital Bochum, Ruhr-University Bochum, Bochum, Germany., Lambert M; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Leopold K; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Vivantes Hospital at Urban and Vivantes Hospital at Friedrichshain, Berlin, Germany., Maicher B; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany., Matura S; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany., Mennigen E; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany., Reif A; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany., Ritter P; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany., Sauer C; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany., Stamm T; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charté Universitätsmedizin Berlin, Berlin, Germany; Brandenburg Theodor Fontane, Neuruppin, Germany; Department of Psychiatry, Psychotherapy and Psychosomatic, Hospitals of Ruppin - Medical School, Germany., Pfennig A; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany. Electronic address: andrea.pfennig@ukdd.de.
Source: Journal of affective disorders [J Affect Disord] 2026 Jun 15; Vol. 403, pp. 121419. Date of Electronic Publication: 2026 Feb 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Contribution of depressive symptom load on prediction of transition to bipolar disorders: Results from the prospective-longitudinal multi-method Early-BipoLife study.
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  Data: <searchLink fieldCode="AU" term="%22Petersen+T%22">Petersen T</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Martini+J%22">Martini J</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Bauer+M%22">Bauer M</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Bechdolf+A%22">Bechdolf A</searchLink>; Department of Psychiatry, Psychotherapy and Psychosomatics, Vivantes Hospital at Urban and Vivantes Hospital at Friedrichshain, Berlin, Germany; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charté Universitätsmedizin Berlin, Berlin, Germany; Brandenburg Theodor Fontane, Neuruppin, Germany.<br /><searchLink fieldCode="AU" term="%22Bermpohl+F%22">Bermpohl F</searchLink>; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charté Universitätsmedizin Berlin, Berlin, Germany; Brandenburg Theodor Fontane, Neuruppin, Germany.<br /><searchLink fieldCode="AU" term="%22Berndt+C%22">Berndt C</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Bröckel-Bundt+KL%22">Bröckel-Bundt KL</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Sperling+T%22">Sperling T</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Correll+CU%22">Correll CU</searchLink>; Department of Child- and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany; Department of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dannlowski+U%22">Dannlowski U</searchLink>; Institute for Translational Psychiatry, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Falkenberg+I%22">Falkenberg I</searchLink>; Department for Psychiatry and Psychotherapy, University Hospital Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Fallgatter+AJ%22">Fallgatter AJ</searchLink>; Tübingen Center for Mental Health (TüCMH), Department of General Psychiatry and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Fusar-Poli+P%22">Fusar-Poli P</searchLink>; EPIC Lab, Department of Psychosis Studies, King's College London, London, UK; Department of Brain and Behavioral Health Sciences, University of Pavia, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Jansen+A%22">Jansen A</searchLink>; Department for Psychiatry and Psychotherapy, University Hospital Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Juckel+G%22">Juckel G</searchLink>; Department for Psychiatry and Psychotherapy, University Hospital Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kircher+T%22">Kircher T</searchLink>; Department for Psychiatry and Psychotherapy, University Hospital Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kittel-Schneider+S%22">Kittel-Schneider S</searchLink>; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Würzburg, Würzburg, Germany; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland.<br /><searchLink fieldCode="AU" term="%22Krüger-Özgürdal+S%22">Krüger-Özgürdal S</searchLink>; Department of Psychiatry and Psychotherapy, LWL-University Hospital Bochum, Ruhr-University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Lambert+M%22">Lambert M</searchLink>; Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Leopold+K%22">Leopold K</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, Vivantes Hospital at Urban and Vivantes Hospital at Friedrichshain, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Maicher+B%22">Maicher B</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Matura+S%22">Matura S</searchLink>; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Mennigen+E%22">Mennigen E</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Reif+A%22">Reif A</searchLink>; Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt am Main, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Ritter+P%22">Ritter P</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Sauer+C%22">Sauer C</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Stamm+T%22">Stamm T</searchLink>; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charté Universitätsmedizin Berlin, Berlin, Germany; Brandenburg Theodor Fontane, Neuruppin, Germany; Department of Psychiatry, Psychotherapy and Psychosomatic, Hospitals of Ruppin - Medical School, Germany.<br /><searchLink fieldCode="AU" term="%22Pfennig+A%22">Pfennig A</searchLink>; Department of Psychiatry and Psychotherapy, University Hospital, TUD Dresden University of Technology, Dresden, Germany. Electronic address: andrea.pfennig@ukdd.de.
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