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cGAS-IFN-I responses by extracting nuclear DNA from dying cells via nucleocytosis.

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Title: cGAS-IFN-I responses by extracting nuclear DNA from dying cells via nucleocytosis.
Authors: Negishi H; Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. hnegishi@ims.u-tokyo.ac.jp.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. hnegishi@ims.u-tokyo.ac.jp.; Laboratory of Immunology and Infection Control, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan. hnegishi@ims.u-tokyo.ac.jp.; The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan. hnegishi@ims.u-tokyo.ac.jp., Wada Y; Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Shirasaki Y; Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Hayashi T; Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan., Kubota Y; Division of Cell Signaling and Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Iwasaki T; Research and Development Group, Hitachi, Ltd., Ibaraki, Japan., Kurosawa M; Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Ban T; Department of Immunology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan., Muto D; Laboratory of Evolutionary Oncology, Chiba Cancer Center Research Institute, Chiba, Japan.; Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Chiba, Japan., Suenaga Y; Laboratory of Evolutionary Oncology, Chiba Cancer Center Research Institute, Chiba, Japan., Kojima T; Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Matsuda Y; Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Irish SL; Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Dodo K; Synthetic Organic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, Saitama, Japan.; Catalysis and Integrated Research Group, RIKEN Center for Sustainable Resource Science, Saitama, Japan., Suzuki T; Division of RNA and gene regulation, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Yamagishi M; Live Cell Diagnosis, Ltd., Saitama, Japan., Temizoz B; Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan., Yoshimori A; Institute for Theoretical Medicine, Inc., Kanagawa, Japan., Kanai C; INTAGE Healthcare, Inc., Osaka, Japan., Nagasaki Y; Department of Infectious Diseases, NHO Kyushu Medical Center, Fukuoka, Japan., Ohmuraya M; Department of Genetics, School of Medicine, Hyogo Medical University, Hyogo, Japan., Tamura T; Department of Immunology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.; Advanced Medical Research Center, Yokohama City University, Kanagawa, Japan., Iwama A; The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan.; Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Laboratory of Cellular and Molecular Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan., Inada T; The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan.; Division of RNA and gene regulation, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Kuroda E; Department of Immunology, Hyogo Medical University School of Medicine, Hyogo, Japan., Kobiyama K; Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan.; Division of Rheumatology, Department of medicine, University of California San Diego, La Jolla, CA, USA., Toyama-Sorimachi N; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Takekawa M; The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan.; Division of Cell Signaling and Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Coban C; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan.; Division of Malaria Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Ishii KJ; Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. kenishii@ims.u-tokyo.ac.jp.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. kenishii@ims.u-tokyo.ac.jp.; The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan. kenishii@ims.u-tokyo.ac.jp.; Laboratory of Vaccine Science, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan. kenishii@ims.u-tokyo.ac.jp.
Source: Nature communications [Nat Commun] 2026 Feb 18; Vol. 17 (1), pp. 1658. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: cGAS-IFN-I responses by extracting nuclear DNA from dying cells via nucleocytosis.
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Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan.; Division of Rheumatology, Department of medicine, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Toyama-Sorimachi+N%22">Toyama-Sorimachi N</searchLink>; International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Takekawa+M%22">Takekawa M</searchLink>; The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan.; Division of Cell Signaling and Molecular Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; 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Laboratory of Vaccine Science, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan. kenishii@ims.u-tokyo.ac.jp.
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