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Methods for randomized, blinded, controlled evaluation of putative disease interventions in multilaboratory, preclinical assessment networks.

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Title: Methods for randomized, blinded, controlled evaluation of putative disease interventions in multilaboratory, preclinical assessment networks.
Authors: Lamb J; Department of Physiology and Neuroscience of the Zilkha Neurogenetic Institute of the Keck School of Medicine, Los Angeles, CA, USA. lambj@usc.edu., Nagarkatti K; Department of Physiology and Neuroscience of the Zilkha Neurogenetic Institute of the Keck School of Medicine, Los Angeles, CA, USA., Diniz MA; Biostatistics and Bioinformatics Research Center, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Cabeen R; USC Stevens Neuroimaging and Informatics Institute, Los Angeles, CA, USA., Estrada M; USC Stevens Neuroimaging and Informatics Institute, Los Angeles, CA, USA., Crawford KL; USC Stevens Neuroimaging and Informatics Institute, Los Angeles, CA, USA., Rogatko A; Biostatistics and Bioinformatics Research Center, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Kim S; Biostatistics and Bioinformatics Research Center, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Ayata C; Neurovascular Research Unit, Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.; Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA., Hess DC; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA., Khan MB; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA., Patel RB; Department of Internal Medicine, Division of Hematology, Oncology and Blood and Marrow Transplantation, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Kumskova M; Department of Internal Medicine, Division of Hematology, Oncology and Blood and Marrow Transplantation, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Leira EC; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Department of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA., Chauhan AK; Department of Internal Medicine, Division of Hematology, Oncology and Blood and Marrow Transplantation, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Lyden P; Department of Physiology and Neuroscience of the Zilkha Neurogenetic Institute of the Keck School of Medicine, Los Angeles, CA, USA.; Department of Neurology of the Keck School of Medicine, Los Angeles, CA, USA.
Corporate Authors: SPAN Consortium
Source: Lab animal [Lab Anim (NY)] 2026 Mar; Vol. 55 (3), pp. 74-82. Date of Electronic Publication: 2026 Feb 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Country of Publication: United States NLM ID: 0417737 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1548-4475 (Electronic) Linking ISSN: 00937355 NLM ISO Abbreviation: Lab Anim (NY) Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Lamb+J%22">Lamb J</searchLink>; Department of Physiology and Neuroscience of the Zilkha Neurogenetic Institute of the Keck School of Medicine, Los Angeles, CA, USA. lambj@usc.edu.<br /><searchLink fieldCode="AU" term="%22Nagarkatti+K%22">Nagarkatti K</searchLink>; Department of Physiology and Neuroscience of the Zilkha Neurogenetic Institute of the Keck School of Medicine, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Diniz+MA%22">Diniz MA</searchLink>; Biostatistics and Bioinformatics Research Center, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Cabeen+R%22">Cabeen R</searchLink>; USC Stevens Neuroimaging and Informatics Institute, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Estrada+M%22">Estrada M</searchLink>; USC Stevens Neuroimaging and Informatics Institute, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Crawford+KL%22">Crawford KL</searchLink>; USC Stevens Neuroimaging and Informatics Institute, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rogatko+A%22">Rogatko A</searchLink>; Biostatistics and Bioinformatics Research Center, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Biostatistics and Bioinformatics Research Center, Samuel Oschin Comprehensive Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ayata+C%22">Ayata C</searchLink>; Neurovascular Research Unit, Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.; Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hess+DC%22">Hess DC</searchLink>; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Khan+MB%22">Khan MB</searchLink>; Department of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Patel+RB%22">Patel RB</searchLink>; Department of Internal Medicine, Division of Hematology, Oncology and Blood and Marrow Transplantation, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Kumskova+M%22">Kumskova M</searchLink>; Department of Internal Medicine, Division of Hematology, Oncology and Blood and Marrow Transplantation, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Leira+EC%22">Leira EC</searchLink>; Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Department of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.; Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Chauhan+AK%22">Chauhan AK</searchLink>; Department of Internal Medicine, Division of Hematology, Oncology and Blood and Marrow Transplantation, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.<br /><searchLink fieldCode="AU" term="%22Lyden+P%22">Lyden P</searchLink>; Department of Physiology and Neuroscience of the Zilkha Neurogenetic Institute of the Keck School of Medicine, Los Angeles, CA, USA.; Department of Neurology of the Keck School of Medicine, Los Angeles, CA, USA.
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