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MSN Templated with L-Dopa Amide Derivatives Outperforms the Efficiency of Free-L-Dopa in Reducing Parkinson's Behavioral Dysfunction in Mice.

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Title: MSN Templated with L-Dopa Amide Derivatives Outperforms the Efficiency of Free-L-Dopa in Reducing Parkinson's Behavioral Dysfunction in Mice.
Authors: Onrubia-Márquez M; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain., Garcia MM; Area of Pharmacology, Nutrition and Bromatology, Department of Basic Health Sciences, Universidad Rey Juan Carlos, Unidad Asociada de I+D+i Al Instituto de Química Médica (IQM) CSIC-URJC, Alcorcón, Spain.; High Performance Experimental Pharmacology Research Group, Universidad Rey Juan Carlos (PHARMAKOM), Alcorcón, Spain.; Grupo Multidisciplinar de Investigación y Tratamiento del Dolor (i+DOL), Alcorcón, Spain., Navas F; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain., Martínez-Erro S; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain., Martín A; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain., Morales V; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain., Delaval J; École de Biologie Industrielle (EBI), Cergy, France., Merchán-Sánchez L; Area of Histology and Pathological Anatomy, Department of Basic Health Sciences, Universidad Rey Juan Carlos, Alcorcón, Spain., Sánchez-Robles EM; Area of Pharmacology, Nutrition and Bromatology, Department of Basic Health Sciences, Universidad Rey Juan Carlos, Unidad Asociada de I+D+i Al Instituto de Química Médica (IQM) CSIC-URJC, Alcorcón, Spain.; High Performance Experimental Pharmacology Research Group, Universidad Rey Juan Carlos (PHARMAKOM), Alcorcón, Spain.; Grupo Multidisciplinar de Investigación y Tratamiento del Dolor (i+DOL), Alcorcón, Spain., Paniagua NA; Area of Pharmacology, Nutrition and Bromatology, Department of Basic Health Sciences, Universidad Rey Juan Carlos, Unidad Asociada de I+D+i Al Instituto de Química Médica (IQM) CSIC-URJC, Alcorcón, Spain.; High Performance Experimental Pharmacology Research Group, Universidad Rey Juan Carlos (PHARMAKOM), Alcorcón, Spain.; Grupo Multidisciplinar de Investigación y Tratamiento del Dolor (i+DOL), Alcorcón, Spain., Rodríguez-Rivera C; Area of Pharmacology, Nutrition and Bromatology, Department of Basic Health Sciences, Universidad Rey Juan Carlos, Unidad Asociada de I+D+i Al Instituto de Química Médica (IQM) CSIC-URJC, Alcorcón, Spain.; High Performance Experimental Pharmacology Research Group, Universidad Rey Juan Carlos (PHARMAKOM), Alcorcón, Spain.; Grupo Multidisciplinar de Investigación y Tratamiento del Dolor (i+DOL), Alcorcón, Spain., Sanz R; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain.; Instituto de Investigación de Tecnologías para la Sostenibilidad, Universidad Rey Juan Carlos, Móstoles, Spain., Goicoechea C; Area of Pharmacology, Nutrition and Bromatology, Department of Basic Health Sciences, Universidad Rey Juan Carlos, Unidad Asociada de I+D+i Al Instituto de Química Médica (IQM) CSIC-URJC, Alcorcón, Spain.; High Performance Experimental Pharmacology Research Group, Universidad Rey Juan Carlos (PHARMAKOM), Alcorcón, Spain.; Grupo Multidisciplinar de Investigación y Tratamiento del Dolor (i+DOL), Alcorcón, Spain., García-Muñoz RA; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain.; Instituto de Investigación de Tecnologías para la Sostenibilidad, Universidad Rey Juan Carlos, Móstoles, Spain.
Source: International journal of nanomedicine [Int J Nanomedicine] 2026 Feb 12; Vol. 21, pp. 545116. Date of Electronic Publication: 2026 Feb 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN: 1178-2013 (Electronic) Linking ISSN: 11769114 NLM ISO Abbreviation: Int J Nanomedicine Subsets: MEDLINE
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  Data: MSN Templated with L-Dopa Amide Derivatives Outperforms the Efficiency of Free-L-Dopa in Reducing Parkinson's Behavioral Dysfunction in Mice.
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  Data: <searchLink fieldCode="AU" term="%22Onrubia-Márquez+M%22">Onrubia-Márquez M</searchLink>; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain.<br /><searchLink fieldCode="AU" term="%22Garcia+MM%22">Garcia MM</searchLink>; Area of Pharmacology, Nutrition and Bromatology, Department of Basic Health Sciences, Universidad Rey Juan Carlos, Unidad Asociada de I+D+i Al Instituto de Química Médica (IQM) CSIC-URJC, Alcorcón, Spain.; High Performance Experimental Pharmacology Research Group, Universidad Rey Juan Carlos (PHARMAKOM), Alcorcón, Spain.; Grupo Multidisciplinar de Investigación y Tratamiento del Dolor (i+DOL), Alcorcón, Spain.<br /><searchLink fieldCode="AU" term="%22Navas+F%22">Navas F</searchLink>; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-Erro+S%22">Martínez-Erro S</searchLink>; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain.<br /><searchLink fieldCode="AU" term="%22Martín+A%22">Martín A</searchLink>; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain.<br /><searchLink fieldCode="AU" term="%22Morales+V%22">Morales V</searchLink>; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain.<br /><searchLink fieldCode="AU" term="%22Delaval+J%22">Delaval J</searchLink>; École de Biologie Industrielle (EBI), Cergy, France.<br /><searchLink fieldCode="AU" term="%22Merchán-Sánchez+L%22">Merchán-Sánchez L</searchLink>; Area of Histology and Pathological Anatomy, Department of Basic Health Sciences, Universidad Rey Juan Carlos, Alcorcón, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez-Robles+EM%22">Sánchez-Robles EM</searchLink>; Area of Pharmacology, Nutrition and Bromatology, Department of Basic Health Sciences, Universidad Rey Juan Carlos, Unidad Asociada de I+D+i Al Instituto de Química Médica (IQM) CSIC-URJC, Alcorcón, Spain.; High Performance Experimental Pharmacology Research Group, Universidad Rey Juan Carlos (PHARMAKOM), Alcorcón, Spain.; Grupo Multidisciplinar de Investigación y Tratamiento del Dolor (i+DOL), Alcorcón, Spain.<br /><searchLink fieldCode="AU" term="%22Paniagua+NA%22">Paniagua NA</searchLink>; Area of Pharmacology, Nutrition and Bromatology, Department of Basic Health Sciences, Universidad Rey Juan Carlos, Unidad Asociada de I+D+i Al Instituto de Química Médica (IQM) CSIC-URJC, Alcorcón, Spain.; High Performance Experimental Pharmacology Research Group, Universidad Rey Juan Carlos (PHARMAKOM), Alcorcón, Spain.; Grupo Multidisciplinar de Investigación y Tratamiento del Dolor (i+DOL), Alcorcón, Spain.<br /><searchLink fieldCode="AU" term="%22Rodríguez-Rivera+C%22">Rodríguez-Rivera C</searchLink>; Area of Pharmacology, Nutrition and Bromatology, Department of Basic Health Sciences, Universidad Rey Juan Carlos, Unidad Asociada de I+D+i Al Instituto de Química Médica (IQM) CSIC-URJC, Alcorcón, Spain.; High Performance Experimental Pharmacology Research Group, Universidad Rey Juan Carlos (PHARMAKOM), Alcorcón, Spain.; Grupo Multidisciplinar de Investigación y Tratamiento del Dolor (i+DOL), Alcorcón, Spain.<br /><searchLink fieldCode="AU" term="%22Sanz+R%22">Sanz R</searchLink>; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain.; Instituto de Investigación de Tecnologías para la Sostenibilidad, Universidad Rey Juan Carlos, Móstoles, Spain.<br /><searchLink fieldCode="AU" term="%22Goicoechea+C%22">Goicoechea C</searchLink>; Area of Pharmacology, Nutrition and Bromatology, Department of Basic Health Sciences, Universidad Rey Juan Carlos, Unidad Asociada de I+D+i Al Instituto de Química Médica (IQM) CSIC-URJC, Alcorcón, Spain.; High Performance Experimental Pharmacology Research Group, Universidad Rey Juan Carlos (PHARMAKOM), Alcorcón, Spain.; Grupo Multidisciplinar de Investigación y Tratamiento del Dolor (i+DOL), Alcorcón, Spain.<br /><searchLink fieldCode="AU" term="%22García-Muñoz+RA%22">García-Muñoz RA</searchLink>; Department of Chemical and Environmental Technology, Universidad Rey Juan Carlos, Móstoles, Spain.; Instituto de Investigación de Tecnologías para la Sostenibilidad, Universidad Rey Juan Carlos, Móstoles, Spain.
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