CSF protein biomarkers are associated with atrophy and symptom severity in genetic FTD: a GENFI study.

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Title: CSF protein biomarkers are associated with atrophy and symptom severity in genetic FTD: a GENFI study.
Authors: Ullgren A; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden. abbe.ullgren@ki.se.; Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland. abbe.ullgren@ki.se., Rydell MT; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.; Unit for Hereditary Dementias, Theme Inflammation and Aging, Karolinska University Hospital, Solna, Sweden., Bergström S; Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden., Öijerstedt L; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.; Unit for Hereditary Dementias, Theme Inflammation and Aging, Karolinska University Hospital, Solna, Sweden., Olofsson J; Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden., Bouzigues A; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Russell LL; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Foster PH; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Ferry-Bolder E; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., van Swieten JC; Department of Neurology, Erasmus Medical Centre, Rotterdam, Netherlands., Jiskoot LC; Department of Neurology, Erasmus Medical Centre, Rotterdam, Netherlands., Seelaar H; Department of Neurology, Erasmus Medical Centre, Rotterdam, Netherlands., Sanchez-Valle R; Alzheimer's disease and Other Cognitive Disorders Unit, Neurology Service, Institut d'Investigacións Biomèdiques August Pi I Sunyer, Hospital Clínic, University of Barcelona, Barcelona, Spain., Laforce R; Département des Sciences Neurologiques, Faculté de Médecine, Clinique Interdisciplinaire de Mémoire, CHU de Québec, Université Laval, Quebec, QC, Canada., Galimberti D; Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda, Milan, Italy.; Dept. of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy., Vandenberghe R; Laboratory for Cognitive Neurology, Leuven Brain Institute, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Neurology Service, University Hospitals Leuven, Leuven, Belgium., Gerhard A; Division of Neuroscience and Experimental Psychology, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.; Departments of Geriatric Medicine and Nuclear Medicine, University of Duisburg-Essen, Duisburg, Germany., Ducharme S; Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Québec, Canada.; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada., Butler CR; Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, UK.; Department of Brain Sciences, Imperial College London, London, UK., Finger E; Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada., Tartaglia MC; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada., Masellis M; Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Canada., Rowe JB; Department of Clinical Neurosciences, Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK., Synofzik M; Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.; Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Moreno F; Cognitive Disorders Unit, Department of Neurology, Hospital Universitario de Donostia, San Sebastian, Spain.; Neurosciences Area, Group of Neurodegenerative Diseases, Biogipuzkoa Health Research Institute, San Sebastian, Spain., Borroni B; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Rohrer JD; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK., Nilsson P; Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden., Rodriguez-Vieitez E; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.; Unit for Hereditary Dementias, Theme Inflammation and Aging, Karolinska University Hospital, Solna, Sweden., Månberg A; Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden., Westman E; Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden., Graff C; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.; Unit for Hereditary Dementias, Theme Inflammation and Aging, Karolinska University Hospital, Solna, Sweden.
Corporate Authors: Genetic Frontotemporal Dementia Initiative (GENFI)
Source: Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2026 Feb 19. Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 9702341 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-1463 (Electronic) Linking ISSN: 03009564 NLM ISO Abbreviation: J Neural Transm (Vienna) Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: CSF protein biomarkers are associated with atrophy and symptom severity in genetic FTD: a GENFI study.
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  Data: <searchLink fieldCode="AU" term="%22Ullgren+A%22">Ullgren A</searchLink>; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden. abbe.ullgren@ki.se.; Institute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland. abbe.ullgren@ki.se.<br /><searchLink fieldCode="AU" term="%22Rydell+MT%22">Rydell MT</searchLink>; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.; Unit for Hereditary Dementias, Theme Inflammation and Aging, Karolinska University Hospital, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Bergström+S%22">Bergström S</searchLink>; Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Öijerstedt+L%22">Öijerstedt L</searchLink>; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.; Unit for Hereditary Dementias, Theme Inflammation and Aging, Karolinska University Hospital, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Olofsson+J%22">Olofsson J</searchLink>; Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Bouzigues+A%22">Bouzigues A</searchLink>; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Russell+LL%22">Russell LL</searchLink>; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Foster+PH%22">Foster PH</searchLink>; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Ferry-Bolder+E%22">Ferry-Bolder E</searchLink>; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22van+Swieten+JC%22">van Swieten JC</searchLink>; Department of Neurology, Erasmus Medical Centre, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Jiskoot+LC%22">Jiskoot LC</searchLink>; Department of Neurology, Erasmus Medical Centre, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Seelaar+H%22">Seelaar H</searchLink>; Department of Neurology, Erasmus Medical Centre, Rotterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Sanchez-Valle+R%22">Sanchez-Valle R</searchLink>; Alzheimer's disease and Other Cognitive Disorders Unit, Neurology Service, Institut d'Investigacións Biomèdiques August Pi I Sunyer, Hospital Clínic, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Laforce+R%22">Laforce R</searchLink>; Département des Sciences Neurologiques, Faculté de Médecine, Clinique Interdisciplinaire de Mémoire, CHU de Québec, Université Laval, Quebec, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Galimberti+D%22">Galimberti D</searchLink>; Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda, Milan, Italy.; Dept. of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Vandenberghe+R%22">Vandenberghe R</searchLink>; Laboratory for Cognitive Neurology, Leuven Brain Institute, Department of Neurosciences, KU Leuven, Leuven, Belgium.; Neurology Service, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Gerhard+A%22">Gerhard A</searchLink>; Division of Neuroscience and Experimental Psychology, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.; Departments of Geriatric Medicine and Nuclear Medicine, University of Duisburg-Essen, Duisburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ducharme+S%22">Ducharme S</searchLink>; Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, Québec, Canada.; McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Butler+CR%22">Butler CR</searchLink>; Nuffield Department of Clinical Neurosciences, Medical Sciences Division, University of Oxford, Oxford, UK.; Department of Brain Sciences, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Finger+E%22">Finger E</searchLink>; Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Tartaglia+MC%22">Tartaglia MC</searchLink>; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Masellis+M%22">Masellis M</searchLink>; Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Rowe+JB%22">Rowe JB</searchLink>; Department of Clinical Neurosciences, Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Synofzik+M%22">Synofzik M</searchLink>; Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research and Center of Neurology, University of Tübingen, Tübingen, Germany.; Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Moreno+F%22">Moreno F</searchLink>; Cognitive Disorders Unit, Department of Neurology, Hospital Universitario de Donostia, San Sebastian, Spain.; Neurosciences Area, Group of Neurodegenerative Diseases, Biogipuzkoa Health Research Institute, San Sebastian, Spain.<br /><searchLink fieldCode="AU" term="%22Borroni+B%22">Borroni B</searchLink>; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Rohrer+JD%22">Rohrer JD</searchLink>; Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.<br /><searchLink fieldCode="AU" term="%22Nilsson+P%22">Nilsson P</searchLink>; Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Vieitez+E%22">Rodriguez-Vieitez E</searchLink>; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.; Unit for Hereditary Dementias, Theme Inflammation and Aging, Karolinska University Hospital, Solna, Sweden.<br /><searchLink fieldCode="AU" term="%22Månberg+A%22">Månberg A</searchLink>; Division of Affinity Proteomics, Department of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Westman+E%22">Westman E</searchLink>; Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden.<br /><searchLink fieldCode="AU" term="%22Graff+C%22">Graff C</searchLink>; Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet, Solna, Sweden.; Unit for Hereditary Dementias, Theme Inflammation and Aging, Karolinska University Hospital, Solna, Sweden.
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