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Efficacy and tolerability of hypofractionated and dose-boosted radiotherapy for localised prostate cancer: a systematic review and meta-analysis.

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Title: Efficacy and tolerability of hypofractionated and dose-boosted radiotherapy for localised prostate cancer: a systematic review and meta-analysis.
Authors: Miszczyk M; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Collegium Medicum - Faculty of Medicine, WSB University, Dąbrowa Górnicza, Poland., Sohoni N; Yale School of Medicine, New Haven, CT, the United States of America., Smani S; Yale School of Medicine, New Haven, CT, the United States of America., Moll M; MedAustron Ion Therapy Centre, Wiener Neustadt, Austria., Alfarhan AR; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, Prince Saud Bin Jalawi Hospital, Al Ahsa Health Cluster, Al Ahsa, Saudi Arabia., Roessler N; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, Medical University Center Hamburg-Eppendorf, Hamburg, Germany., Miyajima K; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, Jikei University School of Medicine, Tokyo, Japan., Inoue S; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Marvaso G; Department of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy., Mastroleo F; Department of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy., Zamboglou C; Department of Radiation Oncology, German Medical Institute, Limassol, Cyprus., Soeterik TFW; Department of Urology, St. Antonius Hospital, Nieuwegein, Utrecht, the Netherlands; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Zilli T; Radiation Oncology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; Faculty of Medicine, University of Geneva, Geneva, Switzerland; Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland., Terlizzi M; Department of Radiation Oncology, Gustave Roussy, Université Paris Saclay, ONCOSTAT INSERM CEPS U 1018, Villejuif, France., Blanchard P; Department of Radiation Oncology, Gustave Roussy, Université Paris Saclay, ONCOSTAT INSERM CEPS U 1018, Villejuif, France., Rajwa P; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Division of Surgery and Interventional Sciences, University College London and University College London Hospital, London, UK; Second Department of Urology, Centre of Postgraduate Medical Education, Warsaw, Poland., Fazekas T; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, Semmelweis University, Budapest, Hungary., Ploussard G; Department of Urology, La Croix du Sud Hospital, Quint Fonsegrives, France., An Y; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, the United States of America., Leapman MS; Yale School of Medicine, New Haven, CT, the United States of America., Blanck O; Department of Radiation Oncology, University Medical Center Schleswig-Holstein, Kiel, Germany., Jereczek-Fossa BA; Department of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy. Electronic address: barbara.jereczek@ieo.it., Shariat SF; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, the United States of America; Department of Urology, Weill Cornell Medical College, New York, NY, the United States of America; Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Division of Urology, Department of Special Surgery, The University of Jordan, Amman, Jordan; Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria; Research Center for Evidence Medicine, Urology Department Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: shahrokh.shariat@meduniwien.ac.at.
Source: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2026 May; Vol. 218, pp. 111445. Date of Electronic Publication: 2026 Feb 17.
Publication Type: Journal Article; Systematic Review; Meta-Analysis; Review
Journal Info: Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8407192 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0887 (Electronic) Linking ISSN: 01678140 NLM ISO Abbreviation: Radiother Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and tolerability of hypofractionated and dose-boosted radiotherapy for localised prostate cancer: a systematic review and meta-analysis.
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  Data: <searchLink fieldCode="AU" term="%22Miszczyk+M%22">Miszczyk M</searchLink>; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Collegium Medicum - Faculty of Medicine, WSB University, Dąbrowa Górnicza, Poland.<br /><searchLink fieldCode="AU" term="%22Sohoni+N%22">Sohoni N</searchLink>; Yale School of Medicine, New Haven, CT, the United States of America.<br /><searchLink fieldCode="AU" term="%22Smani+S%22">Smani S</searchLink>; Yale School of Medicine, New Haven, CT, the United States of America.<br /><searchLink fieldCode="AU" term="%22Moll+M%22">Moll M</searchLink>; MedAustron Ion Therapy Centre, Wiener Neustadt, Austria.<br /><searchLink fieldCode="AU" term="%22Alfarhan+AR%22">Alfarhan AR</searchLink>; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, Prince Saud Bin Jalawi Hospital, Al Ahsa Health Cluster, Al Ahsa, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Roessler+N%22">Roessler N</searchLink>; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, Medical University Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Miyajima+K%22">Miyajima K</searchLink>; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, Jikei University School of Medicine, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Inoue+S%22">Inoue S</searchLink>; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.<br /><searchLink fieldCode="AU" term="%22Marvaso+G%22">Marvaso G</searchLink>; Department of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mastroleo+F%22">Mastroleo F</searchLink>; Department of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Zamboglou+C%22">Zamboglou C</searchLink>; Department of Radiation Oncology, German Medical Institute, Limassol, Cyprus.<br /><searchLink fieldCode="AU" term="%22Soeterik+TFW%22">Soeterik TFW</searchLink>; Department of Urology, St. Antonius Hospital, Nieuwegein, Utrecht, the Netherlands; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zilli+T%22">Zilli T</searchLink>; Radiation Oncology, Oncology Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland; Faculty of Medicine, University of Geneva, Geneva, Switzerland; Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Terlizzi+M%22">Terlizzi M</searchLink>; Department of Radiation Oncology, Gustave Roussy, Université Paris Saclay, ONCOSTAT INSERM CEPS U 1018, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Blanchard+P%22">Blanchard P</searchLink>; Department of Radiation Oncology, Gustave Roussy, Université Paris Saclay, ONCOSTAT INSERM CEPS U 1018, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Rajwa+P%22">Rajwa P</searchLink>; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Division of Surgery and Interventional Sciences, University College London and University College London Hospital, London, UK; Second Department of Urology, Centre of Postgraduate Medical Education, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Fazekas+T%22">Fazekas T</searchLink>; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, Semmelweis University, Budapest, Hungary.<br /><searchLink fieldCode="AU" term="%22Ploussard+G%22">Ploussard G</searchLink>; Department of Urology, La Croix du Sud Hospital, Quint Fonsegrives, France.<br /><searchLink fieldCode="AU" term="%22An+Y%22">An Y</searchLink>; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT, the United States of America.<br /><searchLink fieldCode="AU" term="%22Leapman+MS%22">Leapman MS</searchLink>; Yale School of Medicine, New Haven, CT, the United States of America.<br /><searchLink fieldCode="AU" term="%22Blanck+O%22">Blanck O</searchLink>; Department of Radiation Oncology, University Medical Center Schleswig-Holstein, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Jereczek-Fossa+BA%22">Jereczek-Fossa BA</searchLink>; Department of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Milan, Italy. Electronic address: barbara.jereczek@ieo.it.<br /><searchLink fieldCode="AU" term="%22Shariat+SF%22">Shariat SF</searchLink>; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, the United States of America; Department of Urology, Weill Cornell Medical College, New York, NY, the United States of America; Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Division of Urology, Department of Special Surgery, The University of Jordan, Amman, Jordan; Karl Landsteiner Institute of Urology and Andrology, Vienna, Austria; Research Center for Evidence Medicine, Urology Department Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: shahrokh.shariat@meduniwien.ac.at.
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