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TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition.

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Title: TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition.
Authors: Weiden EM; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany., Serianz Z; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany., Klingl Y; Immunology, Infection and Pandemic Research IIP, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Munich/Frankfurt, Germany., Jörs S; TUM School of Medicine and Health, Department of Clinical Medicine - Clinical Department for Internal Medicine II, University Medical Center, Technical University of Munich, Munich, Germany., Jaślan D; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany., Keller M; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Castro SP; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany., Mkhitaryan M; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany., Jeridi A; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany., Briukhovetska D; Division of Clinical Pharmacology, Department of Medicine IV, University Hospital Munich, Munich, Germany., Spix B; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany., Scotto Rosato A; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany., Agami A; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany., Schiller HB; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany., Rajan S; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany., Schredelseker J; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany., Fois G; Department of Physiology, University of Ulm, Ulm, Germany., Frick M; Department of Physiology, University of Ulm, Ulm, Germany., Kobold S; Division of Clinical Pharmacology, Department of Medicine IV, University Hospital Munich, Munich, Germany.; German Cancer Consortium (DKTK), partner site Munich, Munich, Germany.; German Center for Lung Research (DZL), partner site Munich, Munich, Germany., Klein M; Institute for Neurophysiology, Hannover Medical School, Hannover, Germany., Geisler F; TUM School of Medicine and Health, Department of Clinical Medicine - Clinical Department for Internal Medicine II, University Medical Center, Technical University of Munich, Munich, Germany., Garcia-Fortanet J; Casma Therapeutics, 201 Brookline Ave, Boston, MA, 02215, USA., Murphy LO; Casma Therapeutics, 201 Brookline Ave, Boston, MA, 02215, USA., Bracher F; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany., Wahl-Schott C; Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University, Munich, Germany., Gudermann T; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany., Dietrich A; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany., Biel M; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany. martin.biel@cup.uni-muenchen.de., Yildirim AÖ; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany. oender.yildirim@helmholtz-muenchen.de., Grimm C; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany. christian.grimm@med.uni-muenchen.de.; Immunology, Infection and Pandemic Research IIP, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Munich/Frankfurt, Germany. christian.grimm@med.uni-muenchen.de.; Department of Pharmacology, Faculty of Medicine, University of Oxford, Oxford, UK. christian.grimm@med.uni-muenchen.de.
Source: The EMBO journal [EMBO J] 2026 Apr; Vol. 45 (7), pp. 2182-2209. Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition.
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  Data: <searchLink fieldCode="AU" term="%22Weiden+EM%22">Weiden EM</searchLink>; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Serianz+Z%22">Serianz Z</searchLink>; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Klingl+Y%22">Klingl Y</searchLink>; Immunology, Infection and Pandemic Research IIP, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Munich/Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Jörs+S%22">Jörs S</searchLink>; TUM School of Medicine and Health, Department of Clinical Medicine - Clinical Department for Internal Medicine II, University Medical Center, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Jaślan+D%22">Jaślan D</searchLink>; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Keller+M%22">Keller M</searchLink>; 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Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany.; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Biel+M%22">Biel M</searchLink>; Department of Pharmacy, Ludwig-Maximilians-University, Munich, Germany. martin.biel@cup.uni-muenchen.de.<br /><searchLink fieldCode="AU" term="%22Yildirim+AÖ%22">Yildirim AÖ</searchLink>; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany. oender.yildirim@helmholtz-muenchen.de.<br /><searchLink fieldCode="AU" term="%22Grimm+C%22">Grimm C</searchLink>; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-University, Munich, Germany. christian.grimm@med.uni-muenchen.de.; Immunology, Infection and Pandemic Research IIP, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Munich/Frankfurt, Germany. christian.grimm@med.uni-muenchen.de.; Department of Pharmacology, Faculty of Medicine, University of Oxford, Oxford, UK. christian.grimm@med.uni-muenchen.de.
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