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A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection.

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Title: A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection.
Authors: Zeng Y; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Yong.Zeng@uhn.ca., Abelman DD; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Singhawansa A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Cheng N; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Fang Y; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Main SC; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Bell E; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Ye W; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Luo P; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Wilson SL; Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada., Stutheit-Zhao EY; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Wong D; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Znassi N; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Chen K; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada., Mohanraj S; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Sanz-Garcia E; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Division of Medical Oncology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada., Notta F; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Ghanekar A; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada., Awadalla P; Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK., Lok BH; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Hoffman MM; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Vector Institute, Toronto, Ontario, Canada., Kim RH; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; The Hospital for Sick Children, Toronto, Ontario, Canada., Zadeh G; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada., De Carvalho DD; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Bratman SV; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Lupien M; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Mathieu.Lupien@uhn.ca.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Mathieu.Lupien@uhn.ca.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada. Mathieu.Lupien@uhn.ca., Pugh TJ; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Trevor.Pugh@utoronto.ca.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Trevor.Pugh@utoronto.ca.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada. Trevor.Pugh@utoronto.ca., He HH; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Hansen.He@uhn.ca.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Hansen.He@uhn.ca.
Source: Nature cancer [Nat Cancer] 2026 Feb; Vol. 7 (2), pp. 384-398. Date of Electronic Publication: 2026 Feb 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE
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  Data: A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection.
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  Data: <searchLink fieldCode="AU" term="%22Zeng+Y%22">Zeng Y</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Yong.Zeng@uhn.ca.<br /><searchLink fieldCode="AU" term="%22Abelman+DD%22">Abelman DD</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Singhawansa+A%22">Singhawansa A</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Cheng+N%22">Cheng N</searchLink>; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Fang+Y%22">Fang Y</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Main+SC%22">Main SC</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bell+E%22">Bell E</searchLink>; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ye+W%22">Ye W</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Luo+P%22">Luo P</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wilson+SL%22">Wilson SL</searchLink>; Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Stutheit-Zhao+EY%22">Stutheit-Zhao EY</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wong+D%22">Wong D</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Division of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Znassi+N%22">Znassi N</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Mohanraj+S%22">Mohanraj S</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Sanz-Garcia+E%22">Sanz-Garcia E</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Division of Medical Oncology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Notta+F%22">Notta F</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Ghanekar+A%22">Ghanekar A</searchLink>; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Awadalla+P%22">Awadalla P</searchLink>; Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lok+BH%22">Lok BH</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Hoffman+MM%22">Hoffman MM</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Vector Institute, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Kim+RH%22">Kim RH</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; The Hospital for Sick Children, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Zadeh+G%22">Zadeh G</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22De+Carvalho+DD%22">De Carvalho DD</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Bratman+SV%22">Bratman SV</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Lupien+M%22">Lupien M</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Mathieu.Lupien@uhn.ca.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Mathieu.Lupien@uhn.ca.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada. Mathieu.Lupien@uhn.ca.<br /><searchLink fieldCode="AU" term="%22Pugh+TJ%22">Pugh TJ</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Trevor.Pugh@utoronto.ca.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Trevor.Pugh@utoronto.ca.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada. Trevor.Pugh@utoronto.ca.<br /><searchLink fieldCode="AU" term="%22He+HH%22">He HH</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. Hansen.He@uhn.ca.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Hansen.He@uhn.ca.
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  Data: <searchLink fieldCode="JN" term="%22101761119%22">Nature cancer</searchLink> [Nat Cancer] 2026 Feb; Vol. 7 (2), pp. 384-398. <i>Date of Electronic Publication: </i>2026 Feb 19.
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